Regioselectivity of the intramolecular biaryl coupling reaction of 3-substituted phenyl 2-iodobenzoate using a palladium reagent

Kazuhiro Maeda, Takuya Matsukihira, Shumpei Saga, Yasuo Takeuchi, Takashi Harayama, Yoshikazu Horino, Hitoshi Abe

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

This study investigated the regioselectivity of the intramolecular biaryl coupling reaction of the phenyl benzoate derivative which possesses a methyl or methoxy group at the meta-position of the phenoxy moiety. The type of base and the presence/absence of the phosphine ligand influenced the product ratio. A transition state model and the regioselectivity of the reaction are discussed.

Original languageEnglish
Pages (from-to)621-628
Number of pages8
JournalHeterocycles
Volume88
Issue number1
DOIs
Publication statusPublished - 2014

ASJC Scopus subject areas

  • Analytical Chemistry
  • Pharmacology
  • Organic Chemistry

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