Regioselectivity in direct arylation of benzanilide possessing oxygen substituent in the benzoyl part using palladium without phosphine ligand

Takashi Harayama, Chie Nagura, Taeko Miyagoe, Yuko Kawata, Hitoshi Abe, Yasuo Takeuchi

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The direct arylation of benzanilide (1) possessing ether oxygen(s) in benzoyl part was examined under phosphine ligand-free conditions, which afforded ortho-product (2) and para-product (3) in very similar ratio to presence of P(o-Tol)3 conditions. This results suggest that bulkiness of palladium under phosphine-free conditions would be comparable to that of P(o-Tol)3 conditions.

Original languageEnglish
Pages (from-to)2609-2616
Number of pages8
JournalHeterocycles
Volume81
Issue number11
DOIs
Publication statusPublished - 2010

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phosphine
Regioselectivity
Palladium
Oxygen
Ligands
Ether
benzanilide

ASJC Scopus subject areas

  • Analytical Chemistry
  • Organic Chemistry
  • Pharmacology

Cite this

Regioselectivity in direct arylation of benzanilide possessing oxygen substituent in the benzoyl part using palladium without phosphine ligand. / Harayama, Takashi; Nagura, Chie; Miyagoe, Taeko; Kawata, Yuko; Abe, Hitoshi; Takeuchi, Yasuo.

In: Heterocycles, Vol. 81, No. 11, 2010, p. 2609-2616.

Research output: Contribution to journalArticle

Harayama, Takashi ; Nagura, Chie ; Miyagoe, Taeko ; Kawata, Yuko ; Abe, Hitoshi ; Takeuchi, Yasuo. / Regioselectivity in direct arylation of benzanilide possessing oxygen substituent in the benzoyl part using palladium without phosphine ligand. In: Heterocycles. 2010 ; Vol. 81, No. 11. pp. 2609-2616.
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