@article{fa86011763d646b6b8d59c7027bd418b,
title = "Regioselective Synthesis of γ-Lactones by Iron-Catalyzed Radical Annulation of Alkenes with α-Halocarboxylic Acids and Their Derivatives",
abstract = "An abundant and low toxicity iron catalyst has enabled regioselective annulation of alkenes with α-halocarboxylic acids and their derivatives. The reaction proceeds smoothly without any additional ligands, bases, and additives to afford a variety of γ-lactones in good yields. A proposed reaction pathway through radical annulation is supported by some mechanistic studies, involving radical clock and isotope labeling experiments. The present method was applied to the practical iron-powder-promoted synthesis of γ-lactones.",
author = "Masayuki Iwasaki and Natsumi Miki and Yuichi Ikemoto and Yasuyuki Ura and Yasushi Nishihara",
note = "Funding Information: This work was partly supported by ACT-C, JST, as well as a Grant-in-Aid for Scientific Research (KAKENHI) (No. 16K17901) from JSPS. The authors gratefully thank Ms. Megumi Kosaka and Mr. Motonari Kobayashi (Department of Instrumental Analysis, Advanced Science Research Center, Okayama University) for performing elemental analyses, and the SC-NMR Laboratory (Okayama University) for the NMR spectral measurements. Publisher Copyright: Copyright {\textcopyright} 2018 American Chemical Society.",
year = "2018",
month = jul,
day = "6",
doi = "10.1021/acs.orglett.8b01436",
language = "English",
volume = "20",
pages = "3848--3852",
journal = "Organic Letters",
issn = "1523-7060",
publisher = "American Chemical Society",
number = "13",
}