Regioselective reductive coupling of alkynes and aldehydes leading to allylic alcohols

Kazuhiko Takai, Shuji Sakamoto, Takahiko Isshiki

Research output: Contribution to journalArticlepeer-review

75 Citations (Scopus)

Abstract

(Matrix presented) Treatment of a mixture of a terminal alkyne and an aldehyde with CrCl2 and a catalytic amount of NiCl2 and triphenylphosphine in the pre of water in DMF at 25°C gives a 1,2-disubstituted allylic alcohol regioselectively.

Original languageEnglish
Pages (from-to)653-655
Number of pages3
JournalOrganic Letters
Volume5
Issue number5
DOIs
Publication statusPublished - Mar 6 2003

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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