Regioselective reductive coupling of alkynes and aldehydes leading to allylic alcohols

Kazuhiko Takai, Shuji Sakamoto, Takahiko Isshiki

Research output: Contribution to journalArticle

75 Citations (Scopus)

Abstract

(Matrix presented) Treatment of a mixture of a terminal alkyne and an aldehyde with CrCl2 and a catalytic amount of NiCl2 and triphenylphosphine in the pre of water in DMF at 25°C gives a 1,2-disubstituted allylic alcohol regioselectively.

Original languageEnglish
Pages (from-to)653-655
Number of pages3
JournalOrganic Letters
Volume5
Issue number5
DOIs
Publication statusPublished - Mar 6 2003

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Alkynes
alkynes
aldehydes
Aldehydes
alcohols
Water
matrices
water
allyl alcohol
triphenylphosphine

ASJC Scopus subject areas

  • Molecular Medicine

Cite this

Regioselective reductive coupling of alkynes and aldehydes leading to allylic alcohols. / Takai, Kazuhiko; Sakamoto, Shuji; Isshiki, Takahiko.

In: Organic Letters, Vol. 5, No. 5, 06.03.2003, p. 653-655.

Research output: Contribution to journalArticle

Takai, Kazuhiko ; Sakamoto, Shuji ; Isshiki, Takahiko. / Regioselective reductive coupling of alkynes and aldehydes leading to allylic alcohols. In: Organic Letters. 2003 ; Vol. 5, No. 5. pp. 653-655.
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