Regioselective reductive coupling of alkynes and aldehydes leading to allylic alcohols

Kazuhiko Takai; Shuji Sakamoto; Takahiko Isshiki

doi:10.1021/ol0272996

Regioselective reductive coupling of alkynes and aldehydes leading to allylic alcohols

Kazuhiko Takai, Shuji Sakamoto, Takahiko Isshiki

Research output: Contribution to journal › Article

75 Citations (Scopus)

Abstract

(Matrix presented) Treatment of a mixture of a terminal alkyne and an aldehyde with CrCl₂ and a catalytic amount of NiCl₂ and triphenylphosphine in the pre of water in DMF at 25°C gives a 1,2-disubstituted allylic alcohol regioselectively.

Original language	English
Pages (from-to)	653-655
Number of pages	3
Journal	Organic Letters
Volume	5
Issue number	5
DOIs	https://doi.org/10.1021/ol0272996
Publication status	Published - Mar 6 2003

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ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

Cite this

Takai, K., Sakamoto, S., & Isshiki, T. (2003). Regioselective reductive coupling of alkynes and aldehydes leading to allylic alcohols. Organic Letters, 5(5), 653-655. https://doi.org/10.1021/ol0272996

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abstract = "(Matrix presented) Treatment of a mixture of a terminal alkyne and an aldehyde with CrCl2 and a catalytic amount of NiCl2 and triphenylphosphine in the pre of water in DMF at 25°C gives a 1,2-disubstituted allylic alcohol regioselectively.",

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Access to Document

10.1021/ol0272996