Regional responses of rat brain opioid receptors upon castration and testosterone replacement

H. Takayama, N. Ogawa, Masato Asanuma, Z. Ota

Research output: Contribution to journalArticle

Abstract

Regional responses of rat brain opioid receptors (Op-Rs) upon castration and testosterone replacement were studied using [3H]naloxone (NAL) binding for u-type and [3H]D-Ala2-methionine-enkephalin (ENK) binding for δ-type Op-R. Castration itself produced an increase in specific NAL and ENK binding in the olfactory bulb and thalamus+midbrain. In the hypothalamus, specific ENK binding was increased without any change in NAL binding. After the testosterone replacement in castrated rats, specific NAL binding was decreased and returned to the control level in the thalamus+midbrain, but remained high in the olfactory bulb. Specific ENK binding was decreased and returned to the control level in the olfactory bulb, hypothalamus and thalamus+midbrain. These results indicated that there are regional differences between u- and δ-type Op-R responses to castration and testosterone replacement. Op-R subtypes were regulated differentially by endogenous hormonal changes, such as testosterone.

Original languageEnglish
Pages (from-to)355-358
Number of pages4
JournalResearch Communications in Chemical Pathology and Pharmacology
Volume70
Issue number3
Publication statusPublished - 1990

Fingerprint

Castration
Opioid Receptors
Naloxone
Testosterone
Rats
Enkephalins
Olfactory Bulb
Brain
Mesencephalon
Thalamus
Level control
Hypothalamus
Methionine Enkephalin

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology

Cite this

Regional responses of rat brain opioid receptors upon castration and testosterone replacement. / Takayama, H.; Ogawa, N.; Asanuma, Masato; Ota, Z.

In: Research Communications in Chemical Pathology and Pharmacology, Vol. 70, No. 3, 1990, p. 355-358.

Research output: Contribution to journalArticle

@article{75dc39839c854588b7daf64644f5e1a0,
title = "Regional responses of rat brain opioid receptors upon castration and testosterone replacement",
abstract = "Regional responses of rat brain opioid receptors (Op-Rs) upon castration and testosterone replacement were studied using [3H]naloxone (NAL) binding for u-type and [3H]D-Ala2-methionine-enkephalin (ENK) binding for δ-type Op-R. Castration itself produced an increase in specific NAL and ENK binding in the olfactory bulb and thalamus+midbrain. In the hypothalamus, specific ENK binding was increased without any change in NAL binding. After the testosterone replacement in castrated rats, specific NAL binding was decreased and returned to the control level in the thalamus+midbrain, but remained high in the olfactory bulb. Specific ENK binding was decreased and returned to the control level in the olfactory bulb, hypothalamus and thalamus+midbrain. These results indicated that there are regional differences between u- and δ-type Op-R responses to castration and testosterone replacement. Op-R subtypes were regulated differentially by endogenous hormonal changes, such as testosterone.",
author = "H. Takayama and N. Ogawa and Masato Asanuma and Z. Ota",
year = "1990",
language = "English",
volume = "70",
pages = "355--358",
journal = "Research Communications in Molecular Pathology and Pharmacology",
issn = "1078-0297",
publisher = "PJD Publications Ltd",
number = "3",

}

TY - JOUR

T1 - Regional responses of rat brain opioid receptors upon castration and testosterone replacement

AU - Takayama, H.

AU - Ogawa, N.

AU - Asanuma, Masato

AU - Ota, Z.

PY - 1990

Y1 - 1990

N2 - Regional responses of rat brain opioid receptors (Op-Rs) upon castration and testosterone replacement were studied using [3H]naloxone (NAL) binding for u-type and [3H]D-Ala2-methionine-enkephalin (ENK) binding for δ-type Op-R. Castration itself produced an increase in specific NAL and ENK binding in the olfactory bulb and thalamus+midbrain. In the hypothalamus, specific ENK binding was increased without any change in NAL binding. After the testosterone replacement in castrated rats, specific NAL binding was decreased and returned to the control level in the thalamus+midbrain, but remained high in the olfactory bulb. Specific ENK binding was decreased and returned to the control level in the olfactory bulb, hypothalamus and thalamus+midbrain. These results indicated that there are regional differences between u- and δ-type Op-R responses to castration and testosterone replacement. Op-R subtypes were regulated differentially by endogenous hormonal changes, such as testosterone.

AB - Regional responses of rat brain opioid receptors (Op-Rs) upon castration and testosterone replacement were studied using [3H]naloxone (NAL) binding for u-type and [3H]D-Ala2-methionine-enkephalin (ENK) binding for δ-type Op-R. Castration itself produced an increase in specific NAL and ENK binding in the olfactory bulb and thalamus+midbrain. In the hypothalamus, specific ENK binding was increased without any change in NAL binding. After the testosterone replacement in castrated rats, specific NAL binding was decreased and returned to the control level in the thalamus+midbrain, but remained high in the olfactory bulb. Specific ENK binding was decreased and returned to the control level in the olfactory bulb, hypothalamus and thalamus+midbrain. These results indicated that there are regional differences between u- and δ-type Op-R responses to castration and testosterone replacement. Op-R subtypes were regulated differentially by endogenous hormonal changes, such as testosterone.

UR - http://www.scopus.com/inward/record.url?scp=0025605017&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025605017&partnerID=8YFLogxK

M3 - Article

C2 - 1965518

AN - SCOPUS:0025605017

VL - 70

SP - 355

EP - 358

JO - Research Communications in Molecular Pathology and Pharmacology

JF - Research Communications in Molecular Pathology and Pharmacology

SN - 1078-0297

IS - 3

ER -