Abstract
A 22-year-old woman with severe acute hepatitis underwent a Tc-99m galactosyl human serum albumin (GSA) scan. Intense accumulation was observed in the cephalic region of the right hepatic lobe, whereas the accumulation was reduced in the left lobe and the caudal region of the right lobe. A computed tomographic (CT) scan showed that the left lobe and the caudal region of the right posterior segment had atrophied and become hypodense, which were thought to represent postnecrotic scarring after massive hepatic necrosis. The relatively hyperdense region in the right lobe was slightly swollen and was thought to represent regenerating liver tissue or a "potato liver." Compared with the CT, the regions of elevated Tc-99m GSA accumulation correlated well with the areas of regenerating liver tissue, and the regions with reduced accumulation corresponded closely with the areas of postnecrotic scarring. On a Tc-99m phytate scan, unlike the Tc-99m GSA scan, the radiocolloid accumulation was intense in the left lobe and caudal region of the right lobe and reduced in the cephalic region of the right lobe. Together, the Tc-99m GSA scan and the Tc-99m phytate scan formed a set of exact "nega-posi" images. Biopsy specimens obtained during laparoscopy showed a few hepatocyte columns in the postnecrotic scarred left lobe. Severe disruption of the hepatocytes, prominent inflammatory cell infiltration, and obvious Kupffer cell hypertrophy and clustering were also observed.
| Original language | English |
|---|---|
| Pages (from-to) | 584-588 |
| Number of pages | 5 |
| Journal | Clinical Nuclear Medicine |
| Volume | 27 |
| Issue number | 8 |
| DOIs | |
| Publication status | Published - Aug 2002 |
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Keywords
- Hepatitis
- Kupffer Cell
- Massive Hepatic Necrosis
- Tc-99m Galactosyl Human Serum Albumin Scan
- Tc-99m Phytate Scan
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging
- Radiological and Ultrasound Technology
Cite this
Regional radioactivity discrepancy between Tc-99m GSA and Tc-99m phytate liver scans in a patient with massive hepatic necrosis. / Akaki, Shiro; Saeki, Mototsugu; Iguchi, Toshihiro; Okumura, Yoshihiro; Sato, Shuhei; Kuroda, Masahiro; Kanazawa, Susumu; Hiraki, Yoshio; Uraoka, Toshio; Baba, Nobuyuki; Sakaguchi, Kosaku.
In: Clinical Nuclear Medicine, Vol. 27, No. 8, 08.2002, p. 584-588.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Regional radioactivity discrepancy between Tc-99m GSA and Tc-99m phytate liver scans in a patient with massive hepatic necrosis
AU - Akaki, Shiro
AU - Saeki, Mototsugu
AU - Iguchi, Toshihiro
AU - Okumura, Yoshihiro
AU - Sato, Shuhei
AU - Kuroda, Masahiro
AU - Kanazawa, Susumu
AU - Hiraki, Yoshio
AU - Uraoka, Toshio
AU - Baba, Nobuyuki
AU - Sakaguchi, Kosaku
PY - 2002/8
Y1 - 2002/8
N2 - A 22-year-old woman with severe acute hepatitis underwent a Tc-99m galactosyl human serum albumin (GSA) scan. Intense accumulation was observed in the cephalic region of the right hepatic lobe, whereas the accumulation was reduced in the left lobe and the caudal region of the right lobe. A computed tomographic (CT) scan showed that the left lobe and the caudal region of the right posterior segment had atrophied and become hypodense, which were thought to represent postnecrotic scarring after massive hepatic necrosis. The relatively hyperdense region in the right lobe was slightly swollen and was thought to represent regenerating liver tissue or a "potato liver." Compared with the CT, the regions of elevated Tc-99m GSA accumulation correlated well with the areas of regenerating liver tissue, and the regions with reduced accumulation corresponded closely with the areas of postnecrotic scarring. On a Tc-99m phytate scan, unlike the Tc-99m GSA scan, the radiocolloid accumulation was intense in the left lobe and caudal region of the right lobe and reduced in the cephalic region of the right lobe. Together, the Tc-99m GSA scan and the Tc-99m phytate scan formed a set of exact "nega-posi" images. Biopsy specimens obtained during laparoscopy showed a few hepatocyte columns in the postnecrotic scarred left lobe. Severe disruption of the hepatocytes, prominent inflammatory cell infiltration, and obvious Kupffer cell hypertrophy and clustering were also observed.
AB - A 22-year-old woman with severe acute hepatitis underwent a Tc-99m galactosyl human serum albumin (GSA) scan. Intense accumulation was observed in the cephalic region of the right hepatic lobe, whereas the accumulation was reduced in the left lobe and the caudal region of the right lobe. A computed tomographic (CT) scan showed that the left lobe and the caudal region of the right posterior segment had atrophied and become hypodense, which were thought to represent postnecrotic scarring after massive hepatic necrosis. The relatively hyperdense region in the right lobe was slightly swollen and was thought to represent regenerating liver tissue or a "potato liver." Compared with the CT, the regions of elevated Tc-99m GSA accumulation correlated well with the areas of regenerating liver tissue, and the regions with reduced accumulation corresponded closely with the areas of postnecrotic scarring. On a Tc-99m phytate scan, unlike the Tc-99m GSA scan, the radiocolloid accumulation was intense in the left lobe and caudal region of the right lobe and reduced in the cephalic region of the right lobe. Together, the Tc-99m GSA scan and the Tc-99m phytate scan formed a set of exact "nega-posi" images. Biopsy specimens obtained during laparoscopy showed a few hepatocyte columns in the postnecrotic scarred left lobe. Severe disruption of the hepatocytes, prominent inflammatory cell infiltration, and obvious Kupffer cell hypertrophy and clustering were also observed.
KW - Hepatitis
KW - Kupffer Cell
KW - Massive Hepatic Necrosis
KW - Tc-99m Galactosyl Human Serum Albumin Scan
KW - Tc-99m Phytate Scan
UR - http://www.scopus.com/inward/record.url?scp=0036705888&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0036705888&partnerID=8YFLogxK
U2 - 10.1097/00003072-200208000-00008
DO - 10.1097/00003072-200208000-00008
M3 - Article
C2 - 12170005
AN - SCOPUS:0036705888
VL - 27
SP - 584
EP - 588
JO - Clinical Nuclear Medicine
JF - Clinical Nuclear Medicine
SN - 0363-9762
IS - 8
ER -