Regional distribution of histamine and tele-methylhistamine in the rat, mouse and guinea-pig brain

Ryozo Oishi, Masahiro Nishibori, Kiyomi Saeki

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Regional histamine (HA) and tele-methylhistamine (t-MH) contents were determined in the rat, mouse and guinea-pig brain. The highest HA and t-MH levels were found in the hypothalamus of all species. Fairly high t-MH levels were observed in the amygdala of all species and in the guinea-pig hippocampus. The t-MH/HA ratio was higher in the regions of the telencephalon than in the diencephalon and brainstem. The cerebellum and spinal cord showed extremely low t-MH/HA ratios. These results suggest higher histaminergic neuronal activities in the hypothalamus and some regions of the telencephalon than in other parts of the brain.

Original languageEnglish
Pages (from-to)172-175
Number of pages4
JournalBrain Research
Volume280
Issue number1
DOIs
Publication statusPublished - Nov 28 1983

Keywords

  • amygdala
  • brain
  • histamine
  • histaminergic neuron
  • hypothalamus
  • tele-methylhistamine

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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