Regional differences in the turnover of neuronal histamine in the rat brain

Ryozo Oishi, Masahiro Nishibori, Kiyomi Saeki

Research output: Contribution to journalArticle

83 Citations (Scopus)

Abstract

The turnover rate of histamine (HA) and the half-life of neuronal HA were estimated in 9 regions of the rat brain following pargyline-induced accumulation of tele-methylhistamine (t-MH). The turnover rate was the highest in the hypothalamus (108.7 ng/g/hr). The striatum also showed a high turnover rate (80.2 ng/g/hr) despite much lower levels of HA and t-MH, as compared with the levels in the hypothalamus. The turnover rate was relatively high in the thalamus, cerebral cortex, amygdala and midbrain, but it was very low in the cerebellum. t-MH accumulation in the spinal cord was nil. The HA levels were reduced to various degrees (from nil to less than 40 % of the control) by (S)-α-fluoromethylhistidine, depending on the regions studied. The neuronal HA content of each brain region was subsequently estimated, and the half-life of neuronal HA in each region was calculated. The half-life of neuronal HA was the shortest (7.7 min) in the striatum, while it was long (about 50 min) in the hypothalamus and thalamus. Half-life values of about 20 min were obtained in other regions. These results show the high levels of histaminergic activity in some parts of the telencephalon, thalamus and midbrain as well as the hypothalamus.

Original languageEnglish
Pages (from-to)691-699
Number of pages9
JournalLife Sciences
Volume34
Issue number7
DOIs
Publication statusPublished - Feb 13 1984

Fingerprint

Histamine
Rats
Brain
Hypothalamus
Half-Life
Thalamus
Mesencephalon
Pargyline
Telencephalon
Amygdala
Cerebral Cortex
Cerebellum
Spinal Cord
tele-methylhistamine

ASJC Scopus subject areas

  • Pharmacology

Cite this

Regional differences in the turnover of neuronal histamine in the rat brain. / Oishi, Ryozo; Nishibori, Masahiro; Saeki, Kiyomi.

In: Life Sciences, Vol. 34, No. 7, 13.02.1984, p. 691-699.

Research output: Contribution to journalArticle

Oishi, Ryozo ; Nishibori, Masahiro ; Saeki, Kiyomi. / Regional differences in the turnover of neuronal histamine in the rat brain. In: Life Sciences. 1984 ; Vol. 34, No. 7. pp. 691-699.
@article{ee7d00fd0f1d4ec593f7afc43b81a333,
title = "Regional differences in the turnover of neuronal histamine in the rat brain",
abstract = "The turnover rate of histamine (HA) and the half-life of neuronal HA were estimated in 9 regions of the rat brain following pargyline-induced accumulation of tele-methylhistamine (t-MH). The turnover rate was the highest in the hypothalamus (108.7 ng/g/hr). The striatum also showed a high turnover rate (80.2 ng/g/hr) despite much lower levels of HA and t-MH, as compared with the levels in the hypothalamus. The turnover rate was relatively high in the thalamus, cerebral cortex, amygdala and midbrain, but it was very low in the cerebellum. t-MH accumulation in the spinal cord was nil. The HA levels were reduced to various degrees (from nil to less than 40 {\%} of the control) by (S)-α-fluoromethylhistidine, depending on the regions studied. The neuronal HA content of each brain region was subsequently estimated, and the half-life of neuronal HA in each region was calculated. The half-life of neuronal HA was the shortest (7.7 min) in the striatum, while it was long (about 50 min) in the hypothalamus and thalamus. Half-life values of about 20 min were obtained in other regions. These results show the high levels of histaminergic activity in some parts of the telencephalon, thalamus and midbrain as well as the hypothalamus.",
author = "Ryozo Oishi and Masahiro Nishibori and Kiyomi Saeki",
year = "1984",
month = "2",
day = "13",
doi = "10.1016/0024-3205(84)90234-0",
language = "English",
volume = "34",
pages = "691--699",
journal = "Life Sciences",
issn = "0024-3205",
publisher = "Elsevier Inc.",
number = "7",

}

TY - JOUR

T1 - Regional differences in the turnover of neuronal histamine in the rat brain

AU - Oishi, Ryozo

AU - Nishibori, Masahiro

AU - Saeki, Kiyomi

PY - 1984/2/13

Y1 - 1984/2/13

N2 - The turnover rate of histamine (HA) and the half-life of neuronal HA were estimated in 9 regions of the rat brain following pargyline-induced accumulation of tele-methylhistamine (t-MH). The turnover rate was the highest in the hypothalamus (108.7 ng/g/hr). The striatum also showed a high turnover rate (80.2 ng/g/hr) despite much lower levels of HA and t-MH, as compared with the levels in the hypothalamus. The turnover rate was relatively high in the thalamus, cerebral cortex, amygdala and midbrain, but it was very low in the cerebellum. t-MH accumulation in the spinal cord was nil. The HA levels were reduced to various degrees (from nil to less than 40 % of the control) by (S)-α-fluoromethylhistidine, depending on the regions studied. The neuronal HA content of each brain region was subsequently estimated, and the half-life of neuronal HA in each region was calculated. The half-life of neuronal HA was the shortest (7.7 min) in the striatum, while it was long (about 50 min) in the hypothalamus and thalamus. Half-life values of about 20 min were obtained in other regions. These results show the high levels of histaminergic activity in some parts of the telencephalon, thalamus and midbrain as well as the hypothalamus.

AB - The turnover rate of histamine (HA) and the half-life of neuronal HA were estimated in 9 regions of the rat brain following pargyline-induced accumulation of tele-methylhistamine (t-MH). The turnover rate was the highest in the hypothalamus (108.7 ng/g/hr). The striatum also showed a high turnover rate (80.2 ng/g/hr) despite much lower levels of HA and t-MH, as compared with the levels in the hypothalamus. The turnover rate was relatively high in the thalamus, cerebral cortex, amygdala and midbrain, but it was very low in the cerebellum. t-MH accumulation in the spinal cord was nil. The HA levels were reduced to various degrees (from nil to less than 40 % of the control) by (S)-α-fluoromethylhistidine, depending on the regions studied. The neuronal HA content of each brain region was subsequently estimated, and the half-life of neuronal HA in each region was calculated. The half-life of neuronal HA was the shortest (7.7 min) in the striatum, while it was long (about 50 min) in the hypothalamus and thalamus. Half-life values of about 20 min were obtained in other regions. These results show the high levels of histaminergic activity in some parts of the telencephalon, thalamus and midbrain as well as the hypothalamus.

UR - http://www.scopus.com/inward/record.url?scp=0021326191&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021326191&partnerID=8YFLogxK

U2 - 10.1016/0024-3205(84)90234-0

DO - 10.1016/0024-3205(84)90234-0

M3 - Article

VL - 34

SP - 691

EP - 699

JO - Life Sciences

JF - Life Sciences

SN - 0024-3205

IS - 7

ER -