Regional differences in genetic subgroup frequency in hereditary cerebellar ataxia, and a morphometrical study of brain MR images in SCA1, MJD and SCA6

Utako Nagaoka, Yoshihiro Suzuki, Toru Kawanami, Keiji Kurita, Yukihiro Shikama, Koichi Honda, Koji Abe, Takashi Nakajima, Takeo Kato

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Molecular genetic assessments of 69 individuals in 44 families with hereditary cerebellar ataxia (HCA) were made to determine the relative frequencies of subtypes of HCA in Yamagata, Japan. Fifteen families (34%) had SCA1, none had SCA2, nine (20%) had MJD, five (11%) had SCA6 and nine (20%) had DRPLA. These findings differ markedly from those in other regions of Japan and the rest of the world. A morphometrical study of the brain MR images also was made on 38 individuals with SCAt (n = 14), MJD (n = 8) or SCA6 (n = 16). In SCA1, the ventral pons was atrophic in proportion to the amount of cerebellar atrophy. In MJD, both the pons and the cerebellum were atrophic, cerebellar atrophy being less pronounced than that in SCA1 and SCA6. While both the major and minor axes of the ventral pons were proportionally decreased in SCA1, the minor axis was more decreased than the major axis in MJD. In SCA6, a mild reduction in the ratio of the ventral pontine area to the posterior fossa area (Pv/PF) was observed as well as obvious cerebellar atrophy. These findings indicate that in MR images SCA1, MJD and SCA6 show different atrophic features of the cerebellum and brainstem.

Original languageEnglish
Pages (from-to)187-194
Number of pages8
JournalJournal of the neurological sciences
Volume164
Issue number2
DOIs
Publication statusPublished - Apr 1 1999
Externally publishedYes

Keywords

  • CAG repeat
  • MJD
  • Magnetic resonance imaging
  • Morphometry
  • SCA1
  • SCA6

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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