Regio- and stereoselective preparation of silyl enol ethers by alkylidenation of silyl esters

Kazuhiko Takai, Yasutaka Kataoka, Takashi Okazoe, Kiitiro Utimoto

Research output: Contribution to journalArticle

43 Citations (Scopus)


Treatment of trimethylsilyl esters with a reagent for alkylidenation of carbonyl groups derived from 1,1-dibromoalkane, zinc, TiCl4, and TMEDA in THF gives Z-trimethylsilyl enol ethers in a regio- and stereoselective manner.

Original languageEnglish
Pages (from-to)1065-1068
Number of pages4
JournalTetrahedron Letters
Issue number9
Publication statusPublished - 1988


ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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