Regenerative medicine for epilepsy: From basic research to clinical application

Takao Yasuhara, Takashi Agari, Masahiro Kameda, Akihiko Kondo, Satoshi Kuramoto, Meng Jing, Tatsuya Sasaki, Atsuhiko Toyoshima, Susumu Sasada, Kenichiro Sato, Aiko Shinko, Takaaki Wakamori, Yu Okuma, Yasuyuki Miyoshi, Naoki Tajiri, Cesario V. Borlongan, Isao Date

Research output: Contribution to journalReview article

6 Citations (Scopus)

Abstract

Epilepsy is a chronic neurological disorder, which presents with various forms of seizures. Traditional treatments, including medication using antiepileptic drugs, remain the treatment of choice for epilepsy. Recent development in surgical techniques and approaches has improved treatment outcomes. However, several epileptic patients still suffer from intractable seizures despite the advent of the multimodality of therapies. In this article, we initially provide an overview of clinical presentation of epilepsy then describe clinically relevant animal models of epilepsy. Subsequently, we discuss the concepts of regenerative medicine including cell therapy, neuroprotective agents, and electrical stimulation, which are reviewed within the context of our data.

Original languageEnglish
Pages (from-to)23390-23401
Number of pages12
JournalInternational journal of molecular sciences
Volume14
Issue number12
DOIs
Publication statusPublished - Nov 28 2013

Keywords

  • Brain-derived neurotrophic factor (BDNF)
  • Electrical stimulation
  • Erythropoietin
  • GABAergic neuron
  • Kainic acid
  • Kindling
  • Neural stem cell

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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  • Cite this

    Yasuhara, T., Agari, T., Kameda, M., Kondo, A., Kuramoto, S., Jing, M., Sasaki, T., Toyoshima, A., Sasada, S., Sato, K., Shinko, A., Wakamori, T., Okuma, Y., Miyoshi, Y., Tajiri, N., Borlongan, C. V., & Date, I. (2013). Regenerative medicine for epilepsy: From basic research to clinical application. International journal of molecular sciences, 14(12), 23390-23401. https://doi.org/10.3390/ijms141223390