Regeneration of the mandibular head from grafted periosteum

Takaaki Ueno, Toshimasa Kagawa, Jyoji Fukunaga, Nobuyoshi Mizukawa, Miwa Kanou, Takashi Fujii, Toshio Sugahara, Toshio Yamamoto

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Grafted periosteum has a rich potential to induce heterotopic bone formation. In the current study the authors investigate whether autogenous periosteal grafts can regenerate the mandibular head in a rabbit model. They removed the mandibular head of Japanese white rabbits and grafted tibial periosteum to the cut surface of the mandible. Grafted periosteum was observed histologically and radiographically at day 7, 14, 21, and 45 after surgery. At day 7 after grafting, grafted tissue showed remarkable cell proliferation. By 14 days these cells had differentiated into chondrocytes to form cartilage, and endochondral ossification took place after 21 days. At 45 days after surgery, soft X-ray findings showed a newly formed mandibular head, which was similar histologically to that of a normal mandibular head. The cut mandible without periosteal graft showed no regeneration. These findings indicate that grafted periosteum can regenerate the mandibular head without special procedures such as bone fixation in a rabbit model, and suggest that this technique may be useful clinically.

Original languageEnglish
Pages (from-to)77-83
Number of pages7
JournalAnnals of Plastic Surgery
Volume51
Issue number1
Publication statusPublished - Jul 1 2003

Fingerprint

Periosteum
Regeneration
Head
Rabbits
Mandible
Osteogenesis
Transplants
Tissue Transplantation
Chondrocytes
Ambulatory Surgical Procedures
Cartilage
Cell Proliferation
X-Rays
Bone and Bones

ASJC Scopus subject areas

  • Surgery

Cite this

Ueno, T., Kagawa, T., Fukunaga, J., Mizukawa, N., Kanou, M., Fujii, T., ... Yamamoto, T. (2003). Regeneration of the mandibular head from grafted periosteum. Annals of Plastic Surgery, 51(1), 77-83.

Regeneration of the mandibular head from grafted periosteum. / Ueno, Takaaki; Kagawa, Toshimasa; Fukunaga, Jyoji; Mizukawa, Nobuyoshi; Kanou, Miwa; Fujii, Takashi; Sugahara, Toshio; Yamamoto, Toshio.

In: Annals of Plastic Surgery, Vol. 51, No. 1, 01.07.2003, p. 77-83.

Research output: Contribution to journalArticle

Ueno, T, Kagawa, T, Fukunaga, J, Mizukawa, N, Kanou, M, Fujii, T, Sugahara, T & Yamamoto, T 2003, 'Regeneration of the mandibular head from grafted periosteum', Annals of Plastic Surgery, vol. 51, no. 1, pp. 77-83.
Ueno T, Kagawa T, Fukunaga J, Mizukawa N, Kanou M, Fujii T et al. Regeneration of the mandibular head from grafted periosteum. Annals of Plastic Surgery. 2003 Jul 1;51(1):77-83.
Ueno, Takaaki ; Kagawa, Toshimasa ; Fukunaga, Jyoji ; Mizukawa, Nobuyoshi ; Kanou, Miwa ; Fujii, Takashi ; Sugahara, Toshio ; Yamamoto, Toshio. / Regeneration of the mandibular head from grafted periosteum. In: Annals of Plastic Surgery. 2003 ; Vol. 51, No. 1. pp. 77-83.
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