Regeneration inducers in limb regeneration

Akira Sato, Kazumasa Mitogawa, Aki Makanae

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Limb regeneration ability, which can be observed in amphibians, has been investigated as a representative phenomenon of organ regeneration. Recently, an alternative experimental system called the accessory limb model was developed to investigate early regulation of amphibian limb regeneration. The accessory limb model contributed to identification of limb regeneration inducers in urodele amphibians. Furthermore, the accessory limb model may be applied to other species to explore universality of regeneration mechanisms. This review aims to connect the insights recently gained to emboss universality of regeneration mechanisms among species. The defined molecules (BMP7 (or2) + FGF2 + FGF8) can transform skin wound healing to organ (limb) regeneration responses. The same molecules can initiate regeneration responses in some species.

Original languageEnglish
Pages (from-to)421-429
Number of pages9
JournalDevelopment Growth and Differentiation
Volume57
Issue number6
DOIs
Publication statusPublished - Aug 1 2015

Fingerprint

Regeneration
Extremities
Amphibians
Fibroblast Growth Factor 2
Wound Healing
Skin

Keywords

  • Accessory limb model
  • Axolotl
  • Blastema
  • Limb regeneration
  • Xenopus

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

Cite this

Regeneration inducers in limb regeneration. / Sato, Akira; Mitogawa, Kazumasa; Makanae, Aki.

In: Development Growth and Differentiation, Vol. 57, No. 6, 01.08.2015, p. 421-429.

Research output: Contribution to journalArticle

Sato, Akira ; Mitogawa, Kazumasa ; Makanae, Aki. / Regeneration inducers in limb regeneration. In: Development Growth and Differentiation. 2015 ; Vol. 57, No. 6. pp. 421-429.
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