Refractory childhood epilepsy and factors related to refractoriness

Yoko Ohtsuka, Harumi Yoshinaga, Katsuhiro Kobayashi

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

To clarify the characteristics of refractory childhood epilepsy, we compared recent refractory cases and those of approximately 15 years ago, all of which were seen at the Okayama University Hospital. We also analyzed predictive factors related to refractoriness in the recent refractory cases. Among the recent refractory cases, the proportion of localization-related epilepsies increased, and the proportion of generalized epilepsies decreased compared to historical cases. In generalized epilepsies, the proportion of cases with Lennox-Gastaut syndrome decreased to less than half. In localization-related epilepsies, the proportion of cases with frontal lobe epilepsy increased. The proportion of cases with unknown causes decreased to less than half. Of the cases with known causes, postencephalitis/postencephalopathy and focal cortical malformation, including tuberous sclerosis, accounted for most of the cases. More of the recent refractory cases were treated with high-dose AED monotherapy, compared to more polytherapy in the cases of 15 years earlier. The following factors were related to future refractoriness: less than 1 year of age at onset of seizures, the presence of underlying pathology, status epilepticus, changes in type of epilepsy during the clinical course, and neonatal seizures. Regarding EEG findings of cases that had localization-related epilepsies at the end of follow-up, focal spike-waves associated with diffuse spike-waves on the first EEGs indicated future refractoriness.

Original languageEnglish
Pages (from-to)14-17
Number of pages4
JournalEpilepsia
Volume41
Issue numberSUPPL. 9
Publication statusPublished - 2000

Fingerprint

Partial Epilepsy
Generalized Epilepsy
Epilepsy
Electroencephalography
Seizures
Frontal Lobe Epilepsy
Tuberous Sclerosis
Status Epilepticus
Age of Onset
Pathology

Keywords

  • Follow-up study
  • Frontal lobe epilepsy
  • Lennox-Gastaut syndrome
  • Prognosis
  • Refractory epilepsy

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Refractory childhood epilepsy and factors related to refractoriness. / Ohtsuka, Yoko; Yoshinaga, Harumi; Kobayashi, Katsuhiro.

In: Epilepsia, Vol. 41, No. SUPPL. 9, 2000, p. 14-17.

Research output: Contribution to journalArticle

Ohtsuka, Y, Yoshinaga, H & Kobayashi, K 2000, 'Refractory childhood epilepsy and factors related to refractoriness', Epilepsia, vol. 41, no. SUPPL. 9, pp. 14-17.
Ohtsuka, Yoko ; Yoshinaga, Harumi ; Kobayashi, Katsuhiro. / Refractory childhood epilepsy and factors related to refractoriness. In: Epilepsia. 2000 ; Vol. 41, No. SUPPL. 9. pp. 14-17.
@article{1b1f9997a25042a6b45ac2b94d47a3e9,
title = "Refractory childhood epilepsy and factors related to refractoriness",
abstract = "To clarify the characteristics of refractory childhood epilepsy, we compared recent refractory cases and those of approximately 15 years ago, all of which were seen at the Okayama University Hospital. We also analyzed predictive factors related to refractoriness in the recent refractory cases. Among the recent refractory cases, the proportion of localization-related epilepsies increased, and the proportion of generalized epilepsies decreased compared to historical cases. In generalized epilepsies, the proportion of cases with Lennox-Gastaut syndrome decreased to less than half. In localization-related epilepsies, the proportion of cases with frontal lobe epilepsy increased. The proportion of cases with unknown causes decreased to less than half. Of the cases with known causes, postencephalitis/postencephalopathy and focal cortical malformation, including tuberous sclerosis, accounted for most of the cases. More of the recent refractory cases were treated with high-dose AED monotherapy, compared to more polytherapy in the cases of 15 years earlier. The following factors were related to future refractoriness: less than 1 year of age at onset of seizures, the presence of underlying pathology, status epilepticus, changes in type of epilepsy during the clinical course, and neonatal seizures. Regarding EEG findings of cases that had localization-related epilepsies at the end of follow-up, focal spike-waves associated with diffuse spike-waves on the first EEGs indicated future refractoriness.",
keywords = "Follow-up study, Frontal lobe epilepsy, Lennox-Gastaut syndrome, Prognosis, Refractory epilepsy",
author = "Yoko Ohtsuka and Harumi Yoshinaga and Katsuhiro Kobayashi",
year = "2000",
language = "English",
volume = "41",
pages = "14--17",
journal = "Epilepsia",
issn = "0013-9580",
publisher = "Wiley-Blackwell",
number = "SUPPL. 9",

}

TY - JOUR

T1 - Refractory childhood epilepsy and factors related to refractoriness

AU - Ohtsuka, Yoko

AU - Yoshinaga, Harumi

AU - Kobayashi, Katsuhiro

PY - 2000

Y1 - 2000

N2 - To clarify the characteristics of refractory childhood epilepsy, we compared recent refractory cases and those of approximately 15 years ago, all of which were seen at the Okayama University Hospital. We also analyzed predictive factors related to refractoriness in the recent refractory cases. Among the recent refractory cases, the proportion of localization-related epilepsies increased, and the proportion of generalized epilepsies decreased compared to historical cases. In generalized epilepsies, the proportion of cases with Lennox-Gastaut syndrome decreased to less than half. In localization-related epilepsies, the proportion of cases with frontal lobe epilepsy increased. The proportion of cases with unknown causes decreased to less than half. Of the cases with known causes, postencephalitis/postencephalopathy and focal cortical malformation, including tuberous sclerosis, accounted for most of the cases. More of the recent refractory cases were treated with high-dose AED monotherapy, compared to more polytherapy in the cases of 15 years earlier. The following factors were related to future refractoriness: less than 1 year of age at onset of seizures, the presence of underlying pathology, status epilepticus, changes in type of epilepsy during the clinical course, and neonatal seizures. Regarding EEG findings of cases that had localization-related epilepsies at the end of follow-up, focal spike-waves associated with diffuse spike-waves on the first EEGs indicated future refractoriness.

AB - To clarify the characteristics of refractory childhood epilepsy, we compared recent refractory cases and those of approximately 15 years ago, all of which were seen at the Okayama University Hospital. We also analyzed predictive factors related to refractoriness in the recent refractory cases. Among the recent refractory cases, the proportion of localization-related epilepsies increased, and the proportion of generalized epilepsies decreased compared to historical cases. In generalized epilepsies, the proportion of cases with Lennox-Gastaut syndrome decreased to less than half. In localization-related epilepsies, the proportion of cases with frontal lobe epilepsy increased. The proportion of cases with unknown causes decreased to less than half. Of the cases with known causes, postencephalitis/postencephalopathy and focal cortical malformation, including tuberous sclerosis, accounted for most of the cases. More of the recent refractory cases were treated with high-dose AED monotherapy, compared to more polytherapy in the cases of 15 years earlier. The following factors were related to future refractoriness: less than 1 year of age at onset of seizures, the presence of underlying pathology, status epilepticus, changes in type of epilepsy during the clinical course, and neonatal seizures. Regarding EEG findings of cases that had localization-related epilepsies at the end of follow-up, focal spike-waves associated with diffuse spike-waves on the first EEGs indicated future refractoriness.

KW - Follow-up study

KW - Frontal lobe epilepsy

KW - Lennox-Gastaut syndrome

KW - Prognosis

KW - Refractory epilepsy

UR - http://www.scopus.com/inward/record.url?scp=0034533323&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034533323&partnerID=8YFLogxK

M3 - Article

VL - 41

SP - 14

EP - 17

JO - Epilepsia

JF - Epilepsia

SN - 0013-9580

IS - SUPPL. 9

ER -