Abstract
Pattern formation during animal development is often induced by extracellular signaling molecules, known as morphogens, which are secreted from localized sources. During wing development in Drosophila, Wingless (Wg) is activated by Notch signaling along the dorsal-ventral boundary of the wing imaginal disc and acts as a morphogen to organize gene expression and cell growth. Expression of wg is restricted to a narrow stripe by Wg itself, repressing its own expression in adjacent cells. This refinement of wg expression is essential for specification of the wing margin. Here, we show that a homeodomain protein, Defective proventriculus (Dve), mediates the refinement of wg expression in both the wing disc and embryonic proventriculus, where dve expression requires Wg signaling. Our results provide evidence for a feedback mechanism that establishes the wg-expressing domain through the action of a Wg-induced gene product.
| Original language | English |
|---|---|
| Pages (from-to) | 44-56 |
| Number of pages | 13 |
| Journal | Developmental Biology |
| Volume | 249 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2002 |
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Keywords
- Defective proventriculus
- Drosophila wing imaginal disc
- Morphogen
- Notch
- Pattern formation
- Wingless
ASJC Scopus subject areas
- Developmental Biology
Cite this
Refinement of wingless expression by a Wingless- and Notch-responsive homeodomain protein, defective proventriculus. / Nakagoshi, Hideki; Shirai, Tetsuya; Nabeshima, Yo ichi; Matsuzaki, Fumio.
In: Developmental Biology, Vol. 249, No. 1, 2002, p. 44-56.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Refinement of wingless expression by a Wingless- and Notch-responsive homeodomain protein, defective proventriculus
AU - Nakagoshi, Hideki
AU - Shirai, Tetsuya
AU - Nabeshima, Yo ichi
AU - Matsuzaki, Fumio
PY - 2002
Y1 - 2002
N2 - Pattern formation during animal development is often induced by extracellular signaling molecules, known as morphogens, which are secreted from localized sources. During wing development in Drosophila, Wingless (Wg) is activated by Notch signaling along the dorsal-ventral boundary of the wing imaginal disc and acts as a morphogen to organize gene expression and cell growth. Expression of wg is restricted to a narrow stripe by Wg itself, repressing its own expression in adjacent cells. This refinement of wg expression is essential for specification of the wing margin. Here, we show that a homeodomain protein, Defective proventriculus (Dve), mediates the refinement of wg expression in both the wing disc and embryonic proventriculus, where dve expression requires Wg signaling. Our results provide evidence for a feedback mechanism that establishes the wg-expressing domain through the action of a Wg-induced gene product.
AB - Pattern formation during animal development is often induced by extracellular signaling molecules, known as morphogens, which are secreted from localized sources. During wing development in Drosophila, Wingless (Wg) is activated by Notch signaling along the dorsal-ventral boundary of the wing imaginal disc and acts as a morphogen to organize gene expression and cell growth. Expression of wg is restricted to a narrow stripe by Wg itself, repressing its own expression in adjacent cells. This refinement of wg expression is essential for specification of the wing margin. Here, we show that a homeodomain protein, Defective proventriculus (Dve), mediates the refinement of wg expression in both the wing disc and embryonic proventriculus, where dve expression requires Wg signaling. Our results provide evidence for a feedback mechanism that establishes the wg-expressing domain through the action of a Wg-induced gene product.
KW - Defective proventriculus
KW - Drosophila wing imaginal disc
KW - Morphogen
KW - Notch
KW - Pattern formation
KW - Wingless
UR - http://www.scopus.com/inward/record.url?scp=0036382972&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0036382972&partnerID=8YFLogxK
U2 - 10.1006/dbio.2002.0746
DO - 10.1006/dbio.2002.0746
M3 - Article
C2 - 12217317
AN - SCOPUS:0036382972
VL - 249
SP - 44
EP - 56
JO - Developmental Biology
JF - Developmental Biology
SN - 0012-1606
IS - 1
ER -