Reductive Denitration of Nitroarenes

Myuto Kashihara, M. Ramu Yadav, Yoshiaki Nakao

Research output: Contribution to journalArticlepeer-review

28 Citations (Scopus)

Abstract

The Pd-catalyzed reductive denitration of nitroarenes has been achieved via a direct cleavage of the C-NO2 bonds. The catalytic conditions reported exhibit a broad substrate scope and good functional-group compatibility. Notably, the use of inexpensive propan-2-ol as a mild reductant suppresses the competitive formation of anilines, which are normally formed by other conventional reductions. Mechanistic studies have revealed that alcohols serve as efficient hydride donors in this reaction, possibly through β-hydride elimination from palladium alkoxides.

Original languageEnglish
Pages (from-to)1655-1658
Number of pages4
JournalOrganic Letters
Volume20
Issue number6
DOIs
Publication statusPublished - Mar 16 2018
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

Fingerprint

Dive into the research topics of 'Reductive Denitration of Nitroarenes'. Together they form a unique fingerprint.

Cite this