Reduction of toxicity by reversing the order of infusion of docetaxel and cyclophosphamide

Marie Hanaoka; Hidetaka Kawabata; Tsuguo Iwatani; Toshimi Takano; Daishu Miura

doi:10.1159/000351112

Reduction of toxicity by reversing the order of infusion of docetaxel and cyclophosphamide

Marie Hanaoka, Hidetaka Kawabata, Tsuguo Iwatani, Toshimi Takano, Daishu Miura

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

Background: This retrospective study aimed to determine whether adverse events are more common in docetaxel followed by cyclophosphamide (TC) as compared to the reverse infusion order (rTC). Methods: A retrospective analysis was undertaken at a single institution for 92 consecutive cases treated with TC or rTC for stage I-III breast cancer in a neoadjuvant/adjuvant setting between December 2006 and June 2011. TC was administered during the first 2.5 years and rTC in the latter 2 years. Results: Among the 92 cases, 50 were in the TC arm and 42 in the rTC arm. Fatigue (72.0 vs. 23.8%), edema (48.0 vs. 16.7%), peripheral neuropathy (66.0 vs. 14.3%), myalgia (48.0 vs. 9.5%) and stomatitis (48.0 vs. 16.7%) occurred significantly more often in cases receiving TC compared to rTC, respectively. Conclusion: Nonhematological toxicities are less common in cases receiving rTC in comparison to those receiving TC.

Original language	English
Pages (from-to)	93-98
Number of pages	6
Journal	CHEMOTHERAPY
Volume	59
Issue number	2
DOIs	https://doi.org/10.1159/000351112
Publication status	Published - 2013
Externally published	Yes

Keywords

Adverse effect
Breast cancer
Combination of chemotherapy
Cyclophosphamide
Docetaxel
Sequence of chemotherapy

ASJC Scopus subject areas

Oncology
Pharmacology
Drug Discovery
Pharmacology (medical)
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1159/000351112

Cite this

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title = "Reduction of toxicity by reversing the order of infusion of docetaxel and cyclophosphamide",

abstract = "Background: This retrospective study aimed to determine whether adverse events are more common in docetaxel followed by cyclophosphamide (TC) as compared to the reverse infusion order (rTC). Methods: A retrospective analysis was undertaken at a single institution for 92 consecutive cases treated with TC or rTC for stage I-III breast cancer in a neoadjuvant/adjuvant setting between December 2006 and June 2011. TC was administered during the first 2.5 years and rTC in the latter 2 years. Results: Among the 92 cases, 50 were in the TC arm and 42 in the rTC arm. Fatigue (72.0 vs. 23.8%), edema (48.0 vs. 16.7%), peripheral neuropathy (66.0 vs. 14.3%), myalgia (48.0 vs. 9.5%) and stomatitis (48.0 vs. 16.7%) occurred significantly more often in cases receiving TC compared to rTC, respectively. Conclusion: Nonhematological toxicities are less common in cases receiving rTC in comparison to those receiving TC.",

keywords = "Adverse effect, Breast cancer, Combination of chemotherapy, Cyclophosphamide, Docetaxel, Sequence of chemotherapy",

author = "Marie Hanaoka and Hidetaka Kawabata and Tsuguo Iwatani and Toshimi Takano and Daishu Miura",

note = "Publisher Copyright: Copyright {\textcopyright} 2013 S. Karger AG, Basel.",

year = "2013",

doi = "10.1159/000351112",

language = "English",

volume = "59",

pages = "93--98",

journal = "Chemotherapy",

issn = "0009-3165",

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T1 - Reduction of toxicity by reversing the order of infusion of docetaxel and cyclophosphamide

AU - Hanaoka, Marie

AU - Kawabata, Hidetaka

AU - Iwatani, Tsuguo

AU - Takano, Toshimi

AU - Miura, Daishu

PY - 2013

Y1 - 2013

N2 - Background: This retrospective study aimed to determine whether adverse events are more common in docetaxel followed by cyclophosphamide (TC) as compared to the reverse infusion order (rTC). Methods: A retrospective analysis was undertaken at a single institution for 92 consecutive cases treated with TC or rTC for stage I-III breast cancer in a neoadjuvant/adjuvant setting between December 2006 and June 2011. TC was administered during the first 2.5 years and rTC in the latter 2 years. Results: Among the 92 cases, 50 were in the TC arm and 42 in the rTC arm. Fatigue (72.0 vs. 23.8%), edema (48.0 vs. 16.7%), peripheral neuropathy (66.0 vs. 14.3%), myalgia (48.0 vs. 9.5%) and stomatitis (48.0 vs. 16.7%) occurred significantly more often in cases receiving TC compared to rTC, respectively. Conclusion: Nonhematological toxicities are less common in cases receiving rTC in comparison to those receiving TC.

AB - Background: This retrospective study aimed to determine whether adverse events are more common in docetaxel followed by cyclophosphamide (TC) as compared to the reverse infusion order (rTC). Methods: A retrospective analysis was undertaken at a single institution for 92 consecutive cases treated with TC or rTC for stage I-III breast cancer in a neoadjuvant/adjuvant setting between December 2006 and June 2011. TC was administered during the first 2.5 years and rTC in the latter 2 years. Results: Among the 92 cases, 50 were in the TC arm and 42 in the rTC arm. Fatigue (72.0 vs. 23.8%), edema (48.0 vs. 16.7%), peripheral neuropathy (66.0 vs. 14.3%), myalgia (48.0 vs. 9.5%) and stomatitis (48.0 vs. 16.7%) occurred significantly more often in cases receiving TC compared to rTC, respectively. Conclusion: Nonhematological toxicities are less common in cases receiving rTC in comparison to those receiving TC.

KW - Adverse effect

KW - Breast cancer

KW - Combination of chemotherapy

KW - Cyclophosphamide

KW - Docetaxel

KW - Sequence of chemotherapy

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SN - 0009-3165

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Reduction of toxicity by reversing the order of infusion of docetaxel and cyclophosphamide

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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