Reduction of cerebral infarction in stroke-prone spontaneously hypertensive rats by statins associated with amelioration of oxidative stress

Shoko Nagotani, Takeshi Hayashi, Keiko Sato, Wenri Zhang, Kentaro Deguchi, Isao Nagano, Mikio Shoji, Koji Abe

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55 Citations (Scopus)

Abstract

Background and Purpose-This study aimed to clarify the effect of statins on spontaneous stroke and to examine the antioxidative effect in artificial transient middle cerebral artery occlusion (tMCAO). Methods-Stroke-prone spontaneous hypertensive rats (SHR-SP) were treated with pitavastatin, atorvastatin, simvastatin, or vehicle for 4 weeks. Physiological parameters, serum lipids, and infarct volumes were examined. The markers for oxidative stresses on lipids and DNA were immunohistochemically detected in vehicle-treated or simvastatin-treated SHR-SP with tMCAO. Results-Atorvastatin and simvastatin decreased infarct volumes, with simvastatin most effective. Simvastatin significantly reduced immunoreactivities for oxidative stress markers for lipids and DNA in neurons after tMCAO. Conclusions-The results suggest that the antioxidative properties of statins may be implicated in their beneficial effects against neuronal damage in cerebral ischemia.

Original languageEnglish
Pages (from-to)670-672
Number of pages3
JournalStroke
Volume36
Issue number3
DOIs
Publication statusPublished - Mar 1 2005

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Keywords

  • Cerebral infarction
  • HMG-CoA reductase inhibitors
  • Oxidative stress
  • Rats, inbred SHR

ASJC Scopus subject areas

  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine
  • Advanced and Specialised Nursing

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