Reduction of acrolein dialkyl, acetals with CrCl2. γy-alkoxy substitued allylic chromium reagents for selective synthesis of erythro-1, 2-diols.

Kazuhiko Takai, Kenji Nitta, Kiitiro Utimoto

Research output: Contribution to journalArticlepeer-review

60 Citations (Scopus)

Abstract

Treatment of an aldehyde in THF at -30°C with a reagent derived by reduction of acrolein dialkyl acetal with CrCl2 in the presence of Me3SiI gave 1,2-erythro-3,4-butene-1,2-diol derivatives selectively.

Original languageEnglish
Pages (from-to)5263-5266
Number of pages4
JournalTetrahedron Letters
Volume29
Issue number41
DOIs
Publication statusPublished - 1988
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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