Reduced seroprevalence of hepatitis A virus among Japanese healthcare workers as a risk factor for occupational infection

Nori Yoshioka; Matsuo Deguchi; Hideharu Hagiya; Masanori Kagita; Kazunori Tomono

doi:10.7754/Clin.Lab.2018.180518

Reduced seroprevalence of hepatitis A virus among Japanese healthcare workers as a risk factor for occupational infection

Nori Yoshioka, Matsuo Deguchi, Hideharu Hagiya, Masanori Kagita, Kazunori Tomono

Research output: Contribution to journal › Article › peer-review

Abstract

Background: With the improvement in sanitation and hygiene, the incidence of hepatitis A virus (HAV) infection has declined, and its seroprevalence among Japanese people has been reduced. Universal HAV vaccination is yet to be implemented in Japan, and the healthcare workers (HCWs) are at higher risks of acquiring this infection. We herein report the seroepidemiology of HAV infection among HCWs at Osaka University Hospital. Methods: Between September and October 2017, we collected serum samples submitted to our laboratory for HCWs health examination and tested for the anti-HAV antibody. Results: Overall HAV seropositivity rate was 5.1% (22/436 samples). The seroprevalence was higher among those in the twenties (6.0%) and thirties (8.0%), compared to older age groups. Conclusions: In this age of internationalization, the decreasing immunity for HAV places HCWs at risk of developing the disease. As a preventive measure against occupational infection, HAV vaccination may be needed for Japanese HCWs.

Original language	English
Pages (from-to)	1791-1793
Number of pages	3
Journal	Clinical Laboratory
Volume	64
Issue number	10
DOIs	https://doi.org/10.7754/Clin.Lab.2018.180518
Publication status	Published - 2018
Externally published	Yes

Keywords

Hepatitis A
Occupational infection
Vaccination

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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title = "Reduced seroprevalence of hepatitis A virus among Japanese healthcare workers as a risk factor for occupational infection",

abstract = "Background: With the improvement in sanitation and hygiene, the incidence of hepatitis A virus (HAV) infection has declined, and its seroprevalence among Japanese people has been reduced. Universal HAV vaccination is yet to be implemented in Japan, and the healthcare workers (HCWs) are at higher risks of acquiring this infection. We herein report the seroepidemiology of HAV infection among HCWs at Osaka University Hospital. Methods: Between September and October 2017, we collected serum samples submitted to our laboratory for HCWs health examination and tested for the anti-HAV antibody. Results: Overall HAV seropositivity rate was 5.1% (22/436 samples). The seroprevalence was higher among those in the twenties (6.0%) and thirties (8.0%), compared to older age groups. Conclusions: In this age of internationalization, the decreasing immunity for HAV places HCWs at risk of developing the disease. As a preventive measure against occupational infection, HAV vaccination may be needed for Japanese HCWs.",

keywords = "Hepatitis A, Occupational infection, Vaccination",

author = "Nori Yoshioka and Matsuo Deguchi and Hideharu Hagiya and Masanori Kagita and Kazunori Tomono",

year = "2018",

doi = "10.7754/Clin.Lab.2018.180518",

language = "English",

volume = "64",

pages = "1791--1793",

journal = "Clinical Laboratory",

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TY - JOUR

T1 - Reduced seroprevalence of hepatitis A virus among Japanese healthcare workers as a risk factor for occupational infection

AU - Yoshioka, Nori

AU - Deguchi, Matsuo

AU - Hagiya, Hideharu

AU - Kagita, Masanori

AU - Tomono, Kazunori

PY - 2018

Y1 - 2018

N2 - Background: With the improvement in sanitation and hygiene, the incidence of hepatitis A virus (HAV) infection has declined, and its seroprevalence among Japanese people has been reduced. Universal HAV vaccination is yet to be implemented in Japan, and the healthcare workers (HCWs) are at higher risks of acquiring this infection. We herein report the seroepidemiology of HAV infection among HCWs at Osaka University Hospital. Methods: Between September and October 2017, we collected serum samples submitted to our laboratory for HCWs health examination and tested for the anti-HAV antibody. Results: Overall HAV seropositivity rate was 5.1% (22/436 samples). The seroprevalence was higher among those in the twenties (6.0%) and thirties (8.0%), compared to older age groups. Conclusions: In this age of internationalization, the decreasing immunity for HAV places HCWs at risk of developing the disease. As a preventive measure against occupational infection, HAV vaccination may be needed for Japanese HCWs.

AB - Background: With the improvement in sanitation and hygiene, the incidence of hepatitis A virus (HAV) infection has declined, and its seroprevalence among Japanese people has been reduced. Universal HAV vaccination is yet to be implemented in Japan, and the healthcare workers (HCWs) are at higher risks of acquiring this infection. We herein report the seroepidemiology of HAV infection among HCWs at Osaka University Hospital. Methods: Between September and October 2017, we collected serum samples submitted to our laboratory for HCWs health examination and tested for the anti-HAV antibody. Results: Overall HAV seropositivity rate was 5.1% (22/436 samples). The seroprevalence was higher among those in the twenties (6.0%) and thirties (8.0%), compared to older age groups. Conclusions: In this age of internationalization, the decreasing immunity for HAV places HCWs at risk of developing the disease. As a preventive measure against occupational infection, HAV vaccination may be needed for Japanese HCWs.

KW - Hepatitis A

KW - Occupational infection

KW - Vaccination

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JO - Clinical Laboratory

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Reduced seroprevalence of hepatitis A virus among Japanese healthcare workers as a risk factor for occupational infection

Abstract

Keywords

ASJC Scopus subject areas

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