Reduced levels of mutagen processing potential in the Schistosoma japonicum-infected mouse liver

Hiroyuki Matsuoka, Toshiki Aji, Akira Ishii, Sakae Arimoto, Yusuke Wataya, Hikoya Hayatsu

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Epidemiological studies have shown the presence of a positive correlation between the infection of Schistosoma japonicum and colorectal and/or liver cancers in the humans. To explore the mechanism underlying this correlation, we have investigated the mutagen-activating potentials of the liver homogenate fraction (S9) from Schistosoma japonicum infected mice and those from control mice, by use of the Ames test with 2-acetylaminofluorene, aflatoxin B1 and 3-amino-1-methyl-5H-pyrido[4,3-b]indole (Trp-P-2) as test mutagens. Liver S9 prepared from the infected group at the 15th week after the infection showed a potential significantly lower than that from the control group. The hepatic cytochrome P-450 concentration in the infected mice was persistently low, about a half of that in the uninfected mice, during the period of 6-18 weeks after the infection. Thus, in mice bearing chronic schistosomiasis, mutagen-processing potentials are decreased.

Original languageEnglish
Pages (from-to)153-157
Number of pages5
JournalMutation Research Letters
Volume227
Issue number3
DOIs
Publication statusPublished - Nov 1989

Keywords

  • 2-Acetylaminofluorene
  • Aflatoxin B
  • Ames test
  • Liver cytochrome P-450
  • Schistosoma japonicum
  • Trp-P-2

ASJC Scopus subject areas

  • Medicine(all)

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