Reduced-intensity unrelated donor bone marrow transplantation for hematologic malignancies

Sung Won Kim, Keitaro Matsuo, Takahiro Fukuda, Masamichi Hara, Kosei Matsue, Shuichi Taniguchi, Tetsuya Eto, Mitsune Tanimoto, Atsushi Wake, Kazuo Hatanaka, Shinji Nakao, Yoji Ishida, Mine Harada, Atae Utsunomiya, Masahiro Imamura, Yoshinobu Kanda, Kazutaka Sunami, Fumio Kawano, Yoichi Takaue, Takanori Teshima

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3 Citations (Scopus)

Abstract

To review a current experience of unrelated bone marrow transplantation (BMT) with reduced-intensity conditioning (RIC) regimens, we conducted a nationwide survey with 77 patients (age, 25-68 years). The backbone RIC regimen was a combination of fludarabine or cladribine, busulfan or melphalan and total body irradiation at 2-4 Gy. Five patients died early, but 71 (92%) achieved initial neutrophil recovery. Thereafter, 36 patients (47%) died of therapy-related complications, 23 (30%) of whom died within day 100. Grades II-IV acute graft-versus-host disease (GVHD) occurred in 34 of the 68 evaluable patients (50%). In a multivariate analysis, a regimen containing antithymocyte globulin (ATG) was significantly associated with a decreased risk of acute GVHD (P = 0.041). Thirty-three patients are currently alive with a median follow-up of 439 days (28-2002 days), with an OS of 50% at 1 year. In conclusion, unrelated BMT with RIC regimens can be a curative treatment in a subset of patients.

Original languageEnglish
Pages (from-to)324-330
Number of pages7
JournalInternational Journal of Hematology
Volume88
Issue number3
DOIs
Publication statusPublished - Oct 2008

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Keywords

  • Hematologic malignancy
  • Reduced-intensity conditioning
  • Unrelated transplantation

ASJC Scopus subject areas

  • Hematology

Cite this

Kim, S. W., Matsuo, K., Fukuda, T., Hara, M., Matsue, K., Taniguchi, S., Eto, T., Tanimoto, M., Wake, A., Hatanaka, K., Nakao, S., Ishida, Y., Harada, M., Utsunomiya, A., Imamura, M., Kanda, Y., Sunami, K., Kawano, F., Takaue, Y., & Teshima, T. (2008). Reduced-intensity unrelated donor bone marrow transplantation for hematologic malignancies. International Journal of Hematology, 88(3), 324-330. https://doi.org/10.1007/s12185-008-0163-7