Reduced hepatic drug-metabolising enzyme activities in spontaneously hyperlipidaemic rat as an animal model of hypercholesterolaemia

Minoru Watanabe, Hironori Nakura, Tomonori Tateishi, Masami Tanaka, Toshio Kumai, Shinichi Kobayashi

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

We investigated the activities of hepatic drug-metabolising enzymes and the serum levels of lipids and sex steroids in spontaneously hyperlipidaemic rats (HLR) as compared with those in Sprague-Dawley rats (SDR) of both sexes. The serum cholesterol levels was significantly higher in HLR than in SDR in both sexes. Serum testosterone and estradiol levels of HLR were significantly lower than those of SDR in males and females, respectively. The activities of arylhydroxycarbon hydroxylase (AHH), flavin-containing monooxygenase (FMO) and uridine diphosphate glucuronyl transferase (UDP-GT) of HLR were significantly lower than those of SDR in both sexes. HLR showed significantly lower activities of aniline hydroxylase, aminopyrine N-demethylase and glutathione S-transferase (GST) than SDR only in females. These results suggest that lower activities of hepatic drug-metabolising enzymes in HLR might be related to the significant increase in serum cholesterol, and/or significant decrease in sex steroids, as compared with those in SDR.

Original languageEnglish
Pages (from-to)257-259
Number of pages3
JournalMedical Science Research
Volume24
Issue number4
Publication statusPublished - 1996
Externally publishedYes

Fingerprint

Enzyme activity
Hypercholesterolemia
Sprague Dawley Rats
Rats
Animals
Animal Models
Liver
Enzymes
Pharmaceutical Preparations
Serum
dimethylaniline monooxygenase (N-oxide forming)
Aminopyrine N-Demethylase
Steroids
Cholesterol
Aniline Hydroxylase
Uridine Diphosphate
Transferases
Mixed Function Oxygenases
Glutathione Transferase
Testosterone

Keywords

  • Cholesterol
  • Drug-metabolising enzymes
  • Estradiol
  • Hypercholesterolaemia
  • Spontaneously hyperlipidaemic rat
  • Testosterone

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Reduced hepatic drug-metabolising enzyme activities in spontaneously hyperlipidaemic rat as an animal model of hypercholesterolaemia. / Watanabe, Minoru; Nakura, Hironori; Tateishi, Tomonori; Tanaka, Masami; Kumai, Toshio; Kobayashi, Shinichi.

In: Medical Science Research, Vol. 24, No. 4, 1996, p. 257-259.

Research output: Contribution to journalArticle

Watanabe, Minoru ; Nakura, Hironori ; Tateishi, Tomonori ; Tanaka, Masami ; Kumai, Toshio ; Kobayashi, Shinichi. / Reduced hepatic drug-metabolising enzyme activities in spontaneously hyperlipidaemic rat as an animal model of hypercholesterolaemia. In: Medical Science Research. 1996 ; Vol. 24, No. 4. pp. 257-259.
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