Reduced apolipoprotein E-rich high-density lipoprotein level at birth is restored to the normal range in patients with familial hypercholesterolemia in the first year of life

Hironori Nagasaka, Takashi Miida, Kenichi Hirano, Akemi Ota, Tohru Yorifuji, Tomozumi Takatani, Hirokazu Tsukahara, Masaki Takayanagi, Shu Ping Hui, Kunihiko Kobayashi, Hitoshi Chiba

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background: High-density lipoprotein (HDL) consists of apolipoprotein E (apoE)-rich and apoE-poor HDL particles. ApoE-rich HDL level is high at birth but decreases after birth with reciprocal elevation in low-density lipoprotein (LDL)-cholesterol. Objectives: The objective of the study was to clarify whether apoE-rich HDL decreases after birth in children with familial hypercholesterolemia (FH), a disorder caused by impaired LDL clearance. Methods: We measured apoE-rich HDL-cholesterol and LDL-cholesterol during the first year of life in 10 FH children (one homozygote and nine heterozygotes), 12 non-FH siblings, and 75 healthy controls. Results: At birth, apoE-rich HDL-cholesterol was undetectable in a homozygous FH child and lower in heterozygous FH children than non-FH siblings and controls (4 ± 2 vs. 12 ± 4 and 11 ± 4 mg/dl, P

Original languageEnglish
Pages (from-to)779-783
Number of pages5
JournalJournal of Clinical Endocrinology and Metabolism
Volume93
Issue number3
DOIs
Publication statusPublished - Mar 2008
Externally publishedYes

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Hyperlipoproteinemia Type II
Apolipoproteins E
HDL Lipoproteins
Reference Values
Parturition
Hypercholesterolemia
LDL Cholesterol
HDL Cholesterol
Siblings
Homozygote
Heterozygote
LDL Lipoproteins
apolipoprotein E-rich HDL

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

Cite this

Reduced apolipoprotein E-rich high-density lipoprotein level at birth is restored to the normal range in patients with familial hypercholesterolemia in the first year of life. / Nagasaka, Hironori; Miida, Takashi; Hirano, Kenichi; Ota, Akemi; Yorifuji, Tohru; Takatani, Tomozumi; Tsukahara, Hirokazu; Takayanagi, Masaki; Hui, Shu Ping; Kobayashi, Kunihiko; Chiba, Hitoshi.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 93, No. 3, 03.2008, p. 779-783.

Research output: Contribution to journalArticle

Nagasaka, Hironori ; Miida, Takashi ; Hirano, Kenichi ; Ota, Akemi ; Yorifuji, Tohru ; Takatani, Tomozumi ; Tsukahara, Hirokazu ; Takayanagi, Masaki ; Hui, Shu Ping ; Kobayashi, Kunihiko ; Chiba, Hitoshi. / Reduced apolipoprotein E-rich high-density lipoprotein level at birth is restored to the normal range in patients with familial hypercholesterolemia in the first year of life. In: Journal of Clinical Endocrinology and Metabolism. 2008 ; Vol. 93, No. 3. pp. 779-783.
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AU - Nagasaka, Hironori

AU - Miida, Takashi

AU - Hirano, Kenichi

AU - Ota, Akemi

AU - Yorifuji, Tohru

AU - Takatani, Tomozumi

AU - Tsukahara, Hirokazu

AU - Takayanagi, Masaki

AU - Hui, Shu Ping

AU - Kobayashi, Kunihiko

AU - Chiba, Hitoshi

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AB - Background: High-density lipoprotein (HDL) consists of apolipoprotein E (apoE)-rich and apoE-poor HDL particles. ApoE-rich HDL level is high at birth but decreases after birth with reciprocal elevation in low-density lipoprotein (LDL)-cholesterol. Objectives: The objective of the study was to clarify whether apoE-rich HDL decreases after birth in children with familial hypercholesterolemia (FH), a disorder caused by impaired LDL clearance. Methods: We measured apoE-rich HDL-cholesterol and LDL-cholesterol during the first year of life in 10 FH children (one homozygote and nine heterozygotes), 12 non-FH siblings, and 75 healthy controls. Results: At birth, apoE-rich HDL-cholesterol was undetectable in a homozygous FH child and lower in heterozygous FH children than non-FH siblings and controls (4 ± 2 vs. 12 ± 4 and 11 ± 4 mg/dl, P

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