Recurrent lung cancer in the mediastinum noticed after a living-donor lobar lung transplantation

Shinichi Toyooka, Naohisa Waki, Megumi Okazaki, Katsuya Kato, Masaomi Yamane, Takahiro Oto, Yoshifumi Sano, Hiroshi Date

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


We describe a case of lung cancer in a living-donor lobar lung transplantation (LDLLT) recipient that was identified because of a recurrence in the mediastinum. The patient was a 55-year-old woman who had undergone bilateral LDLLT for nonspecific interstitial pneumonia. She developed dyspnea upon exertion at 15 months after transplantation and was diagnosed as suffering from chronic rejection. A computed tomography scan also revealed enlarged mediastinal lymph nodes (LNs) that were subsequently confirmed as poorly differentiated squamous cell carcinomas. Retrospectively, a small tumor was found in the explanted right lung tissue, the microscopic findings of which were similar to those of the mediastinal lesion. A whole body examination revealed no other lesions; thus we resected the LNs and subsequently irradiated the mediastinum. Recurrent disease appeared in her transplanted lungs 10 months after resection of the LNs, and she died of pneumonia with chronic rejection 2 years and 7 months after transplantation. (Ann Thorac Cardiovasc Surg 2009; 15: 119-122).

Original languageEnglish
Pages (from-to)119-122
Number of pages4
JournalAnnals of Thoracic and Cardiovascular Surgery
Issue number2
Publication statusPublished - Apr 2009


  • Immunosupression
  • Living-donor lobar lung transplantation
  • Lung cancer
  • Lung transplantation

ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine
  • Gastroenterology


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