Recurrence after radiotherapy for gastric mucosa-associated lymphoid tissue (MALT) lymphoma with trisomy 18

Hisashi Ishikawa, Masaya Iwamuro, Hiroyuki Okada, Keisuke Hori, Masahide Kita, Seiji Kawano, Yoshiro Kawahara, Takehiro Tanaka, Eisei Kondo, Tadashi Yoshino, Kazuhide Yamamoto

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

A 36-year-old Japanese woman presented with extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) in the stomach. The gastric lesions only partially improved after eradication therapy for Helicobacter pylori. A fluorescence in situ hybridization analysis revealed no fusion genes of API2-MALT1, although trisomy of chromosome 18 was identified. Radiation therapy was initiated to treat the gastric lymphoma lesions, resulting in complete remission. However, MALT lymphoma recurred in the stomach 16 months later. This case indicates that intensive follow-up is required for MALT lymphoma associated with chromosomal aberrations in order to detect early relapse.

Original languageEnglish
Pages (from-to)911-916
Number of pages6
JournalInternal Medicine
Volume54
Issue number8
DOIs
Publication statusPublished - 2015

Fingerprint

Marginal Zone B-Cell Lymphoma
Gastric Mucosa
Radiotherapy
Recurrence
Stomach
Chromosomes, Human, Pair 18
Gene Fusion
Fluorescence In Situ Hybridization
Helicobacter pylori
Chromosome Aberrations
Trisomy 18
Therapeutics

Keywords

  • Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue
  • Gastric lymphoma
  • MALT lymphoma
  • Trisomy 18

ASJC Scopus subject areas

  • Internal Medicine
  • Medicine(all)

Cite this

Recurrence after radiotherapy for gastric mucosa-associated lymphoid tissue (MALT) lymphoma with trisomy 18. / Ishikawa, Hisashi; Iwamuro, Masaya; Okada, Hiroyuki; Hori, Keisuke; Kita, Masahide; Kawano, Seiji; Kawahara, Yoshiro; Tanaka, Takehiro; Kondo, Eisei; Yoshino, Tadashi; Yamamoto, Kazuhide.

In: Internal Medicine, Vol. 54, No. 8, 2015, p. 911-916.

Research output: Contribution to journalArticle

@article{c506588ba4224a2586cf084d01a9a460,
title = "Recurrence after radiotherapy for gastric mucosa-associated lymphoid tissue (MALT) lymphoma with trisomy 18",
abstract = "A 36-year-old Japanese woman presented with extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) in the stomach. The gastric lesions only partially improved after eradication therapy for Helicobacter pylori. A fluorescence in situ hybridization analysis revealed no fusion genes of API2-MALT1, although trisomy of chromosome 18 was identified. Radiation therapy was initiated to treat the gastric lymphoma lesions, resulting in complete remission. However, MALT lymphoma recurred in the stomach 16 months later. This case indicates that intensive follow-up is required for MALT lymphoma associated with chromosomal aberrations in order to detect early relapse.",
keywords = "Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue, Gastric lymphoma, MALT lymphoma, Trisomy 18",
author = "Hisashi Ishikawa and Masaya Iwamuro and Hiroyuki Okada and Keisuke Hori and Masahide Kita and Seiji Kawano and Yoshiro Kawahara and Takehiro Tanaka and Eisei Kondo and Tadashi Yoshino and Kazuhide Yamamoto",
year = "2015",
doi = "10.2169/internalmedicine.54.3784",
language = "English",
volume = "54",
pages = "911--916",
journal = "Internal Medicine",
issn = "0918-2918",
publisher = "Japanese Society of Internal Medicine",
number = "8",

}

TY - JOUR

T1 - Recurrence after radiotherapy for gastric mucosa-associated lymphoid tissue (MALT) lymphoma with trisomy 18

AU - Ishikawa, Hisashi

AU - Iwamuro, Masaya

AU - Okada, Hiroyuki

AU - Hori, Keisuke

AU - Kita, Masahide

AU - Kawano, Seiji

AU - Kawahara, Yoshiro

AU - Tanaka, Takehiro

AU - Kondo, Eisei

AU - Yoshino, Tadashi

AU - Yamamoto, Kazuhide

PY - 2015

Y1 - 2015

N2 - A 36-year-old Japanese woman presented with extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) in the stomach. The gastric lesions only partially improved after eradication therapy for Helicobacter pylori. A fluorescence in situ hybridization analysis revealed no fusion genes of API2-MALT1, although trisomy of chromosome 18 was identified. Radiation therapy was initiated to treat the gastric lymphoma lesions, resulting in complete remission. However, MALT lymphoma recurred in the stomach 16 months later. This case indicates that intensive follow-up is required for MALT lymphoma associated with chromosomal aberrations in order to detect early relapse.

AB - A 36-year-old Japanese woman presented with extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) in the stomach. The gastric lesions only partially improved after eradication therapy for Helicobacter pylori. A fluorescence in situ hybridization analysis revealed no fusion genes of API2-MALT1, although trisomy of chromosome 18 was identified. Radiation therapy was initiated to treat the gastric lymphoma lesions, resulting in complete remission. However, MALT lymphoma recurred in the stomach 16 months later. This case indicates that intensive follow-up is required for MALT lymphoma associated with chromosomal aberrations in order to detect early relapse.

KW - Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue

KW - Gastric lymphoma

KW - MALT lymphoma

KW - Trisomy 18

UR - http://www.scopus.com/inward/record.url?scp=84927633670&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84927633670&partnerID=8YFLogxK

U2 - 10.2169/internalmedicine.54.3784

DO - 10.2169/internalmedicine.54.3784

M3 - Article

VL - 54

SP - 911

EP - 916

JO - Internal Medicine

JF - Internal Medicine

SN - 0918-2918

IS - 8

ER -