Abstract
We describe an interesting case of a patient with chronic myelogenous leukemia (CML) who developed sustained severe bone marrow aplasia after 2 years and 11 months of interferon-α (IFN-α) therapy but demonstrated recovery of normal hematopoiesis when treated with immunosuppressive therapy with granulocyte-colony stimulating factor (G-CSF). Administration of G-CSF resulted in a partial recovery of hematopoiesis, and after starting immunosuppressive therapy, the patient was no longer dependent on blood transfusions. Moreover, her bone marrow had no Philadelphia chromosome-positive clones. According to the results of the present case, bone marrow recovery can be achieved with immunosuppressive therapy and a fatal outcome avoided, even in CML patients suffering from sustained bone marrow aplasia during IFN-α treatment.
Original language | English |
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Pages (from-to) | 55-59 |
Number of pages | 5 |
Journal | International journal of hematology |
Volume | 77 |
Issue number | 1 |
DOIs | |
Publication status | Published - Jan 2003 |
Keywords
- Bone marrow aplasia
- CML
- Immunosuppressive therapy
- Interferon-α
ASJC Scopus subject areas
- Hematology