Recovery of normal hematopoiesis after severe bone marrow aplasia induced by interferon-α in a patient with chronic myelogenous leukemia

Asahi Hishida, Kazuhito Yamamoto, Chiaki Kato, Toshiya Yokozawa, Nobuhiko Emi, Mitsune Tanimoto, Hidehiko Saito

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

We describe an interesting case of a patient with chronic myelogenous leukemia (CML) who developed sustained severe bone marrow aplasia after 2 years and 11 months of interferon-α (IFN-α) therapy but demonstrated recovery of normal hematopoiesis when treated with immunosuppressive therapy with granulocyte-colony stimulating factor (G-CSF). Administration of G-CSF resulted in a partial recovery of hematopoiesis, and after starting immunosuppressive therapy, the patient was no longer dependent on blood transfusions. Moreover, her bone marrow had no Philadelphia chromosome-positive clones. According to the results of the present case, bone marrow recovery can be achieved with immunosuppressive therapy and a fatal outcome avoided, even in CML patients suffering from sustained bone marrow aplasia during IFN-α treatment.

Original languageEnglish
Pages (from-to)55-59
Number of pages5
JournalInternational journal of hematology
Volume77
Issue number1
DOIs
Publication statusPublished - Jan 2003

Keywords

  • Bone marrow aplasia
  • CML
  • Immunosuppressive therapy
  • Interferon-α

ASJC Scopus subject areas

  • Hematology

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