Recovery from Edema and of Protein Synthesis Differs Between the Cortex and Caudate Following Transient Focal Cerebral Ischemia in Rats

Koji Abe, Tsutomu Araki, Kyuya Kogure

Research output: Contribution to journalArticle

68 Citations (Scopus)

Abstract

Abstract: Postischemic recovery from brain edema and of protein synthesis was examined following 1 h of middle cerebral artery (MCA) occlusion in rats. Recovery from brain edema and of protein synthesis showed a good correlation until 7 days after reperfusion in each area (cerebral cortex or lateral caudate) in the occluded MCA side. However, regional differences in the above types of recovery in the cortex and in the lateral caudate were found for the first time in this experiment. A profound inhibition of protein synthesis and formation of brain edema began sooner in the lateral caudate than in the cortex and continued long after reperfusion. Grades of cerebral blood flow during ischemia and the early period of reperfusion were almost the same in the two regions. Therefore, the regional differences in the above recoveries may not be due to the difference in the blood flow during ischemia and reperfusion, but may be partly attributable to the imbalance of excitatory and inhibitory innervation in the above two areas of the brain, may be due to a distinctive response to ischemic stress, and may be caused also by the potentiative effect of free arachidonate on the excitotoxic mechanism.

Original languageEnglish
Pages (from-to)1470-1476
Number of pages7
JournalJournal of Neurochemistry
Volume51
Issue number5
DOIs
Publication statusPublished - Nov 1988
Externally publishedYes

Keywords

  • Brain edema
  • Focal cerebral ischemia
  • Protein synthesis
  • Rat

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience

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