Reconffgurable protein matrices for prolonged neuroblasts patterning and retraction

Xiaoyue Zhu, Kristen L. Mills, Portia R. Peters, Keiji Naruse, Marie E. Csete, M. D. Thouless, Shuichi Takayama

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Here we present long-term patterning and response studies of neuro blasts on arrays of extracellular matrix (ECM) protein lines fabricated by cracking a polymer-supported thin film and selectively depositing proteins inside the cracks. Neuroblasts cultured for five days on the protein matrix switched between spreading and retraction upon changing the protein line width. This technique provides a novel tool to pursue further understanding of the basic mechanisms of neuroblast pathfinding on adhesion and morphology. Biomedical device design will also benefit from materials engineered with the reconfigurable protein patterns.

Original languageEnglish
Title of host publication2005 3rd IEEE/EMBS Special Topic Conference on Microtechnology in Medicine and Biology
Pages393-395
Number of pages3
DOIs
Publication statusPublished - Dec 1 2005
Externally publishedYes
Event2005 3rd IEEE/EMBS Special Topic Conference on Microtechnology in Medicine and Biology - Oahu, HI, United States
Duration: May 12 2005May 15 2005

Publication series

Name2005 3rd IEEE/EMBS Special Topic Conference on Microtechnology in Medicine and Biology
Volume2005

Other

Other2005 3rd IEEE/EMBS Special Topic Conference on Microtechnology in Medicine and Biology
CountryUnited States
CityOahu, HI
Period5/12/055/15/05

Keywords

  • ECM
  • Micro/nano fabrication
  • Patterning

ASJC Scopus subject areas

  • Engineering(all)

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  • Cite this

    Zhu, X., Mills, K. L., Peters, P. R., Naruse, K., Csete, M. E., Thouless, M. D., & Takayama, S. (2005). Reconffgurable protein matrices for prolonged neuroblasts patterning and retraction. In 2005 3rd IEEE/EMBS Special Topic Conference on Microtechnology in Medicine and Biology (pp. 393-395). [1548485] (2005 3rd IEEE/EMBS Special Topic Conference on Microtechnology in Medicine and Biology; Vol. 2005). https://doi.org/10.1109/MMB.2005.1548485