Reconffgurable protein matrices for prolonged neuroblasts patterning and retraction

Xiaoyue Zhu; Kristen L. Mills; Portia R. Peters; Keiji Naruse; Marie E. Csete; M. D. Thouless; Shuichi Takayama

doi:10.1109/MMB.2005.1548485

Reconffgurable protein matrices for prolonged neuroblasts patterning and retraction

Xiaoyue Zhu, Kristen L. Mills, Portia R. Peters, Keiji Naruse, Marie E. Csete, M. D. Thouless, Shuichi Takayama

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

Here we present long-term patterning and response studies of neuro blasts on arrays of extracellular matrix (ECM) protein lines fabricated by cracking a polymer-supported thin film and selectively depositing proteins inside the cracks. Neuroblasts cultured for five days on the protein matrix switched between spreading and retraction upon changing the protein line width. This technique provides a novel tool to pursue further understanding of the basic mechanisms of neuroblast pathfinding on adhesion and morphology. Biomedical device design will also benefit from materials engineered with the reconfigurable protein patterns.

Original language	English
Title of host publication	2005 3rd IEEE/EMBS Special Topic Conference on Microtechnology in Medicine and Biology
Pages	393-395
Number of pages	3
DOIs	https://doi.org/10.1109/MMB.2005.1548485
Publication status	Published - 2005
Externally published	Yes
Event	2005 3rd IEEE/EMBS Special Topic Conference on Microtechnology in Medicine and Biology - Oahu, HI, United States Duration: May 12 2005 → May 15 2005

Publication series

Name	2005 3rd IEEE/EMBS Special Topic Conference on Microtechnology in Medicine and Biology
Volume	2005

Other

Other	2005 3rd IEEE/EMBS Special Topic Conference on Microtechnology in Medicine and Biology
Country/Territory	United States
City	Oahu, HI
Period	5/12/05 → 5/15/05

Keywords

ECM
Micro/nano fabrication
Patterning

ASJC Scopus subject areas

Engineering(all)

Access to Document

10.1109/MMB.2005.1548485

Cite this

Zhu, X., Mills, K. L., Peters, P. R., Naruse, K., Csete, M. E., Thouless, M. D., & Takayama, S. (2005). Reconffgurable protein matrices for prolonged neuroblasts patterning and retraction. In 2005 3rd IEEE/EMBS Special Topic Conference on Microtechnology in Medicine and Biology (pp. 393-395). [1548485] (2005 3rd IEEE/EMBS Special Topic Conference on Microtechnology in Medicine and Biology; Vol. 2005). https://doi.org/10.1109/MMB.2005.1548485

Reconffgurable protein matrices for prolonged neuroblasts patterning and retraction. / Zhu, Xiaoyue; Mills, Kristen L.; Peters, Portia R. et al.

2005 3rd IEEE/EMBS Special Topic Conference on Microtechnology in Medicine and Biology. 2005. p. 393-395 1548485 (2005 3rd IEEE/EMBS Special Topic Conference on Microtechnology in Medicine and Biology; Vol. 2005).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Zhu, X, Mills, KL, Peters, PR, Naruse, K, Csete, ME, Thouless, MD & Takayama, S 2005, Reconffgurable protein matrices for prolonged neuroblasts patterning and retraction. in 2005 3rd IEEE/EMBS Special Topic Conference on Microtechnology in Medicine and Biology., 1548485, 2005 3rd IEEE/EMBS Special Topic Conference on Microtechnology in Medicine and Biology, vol. 2005, pp. 393-395, 2005 3rd IEEE/EMBS Special Topic Conference on Microtechnology in Medicine and Biology, Oahu, HI, United States, 5/12/05. https://doi.org/10.1109/MMB.2005.1548485

Zhu X, Mills KL, Peters PR, Naruse K, Csete ME, Thouless MD et al. Reconffgurable protein matrices for prolonged neuroblasts patterning and retraction. In 2005 3rd IEEE/EMBS Special Topic Conference on Microtechnology in Medicine and Biology. 2005. p. 393-395. 1548485. (2005 3rd IEEE/EMBS Special Topic Conference on Microtechnology in Medicine and Biology). doi: 10.1109/MMB.2005.1548485

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title = "Reconffgurable protein matrices for prolonged neuroblasts patterning and retraction",

abstract = "Here we present long-term patterning and response studies of neuro blasts on arrays of extracellular matrix (ECM) protein lines fabricated by cracking a polymer-supported thin film and selectively depositing proteins inside the cracks. Neuroblasts cultured for five days on the protein matrix switched between spreading and retraction upon changing the protein line width. This technique provides a novel tool to pursue further understanding of the basic mechanisms of neuroblast pathfinding on adhesion and morphology. Biomedical device design will also benefit from materials engineered with the reconfigurable protein patterns.",

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AU - Thouless, M. D.

AU - Takayama, Shuichi

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ER -

Reconffgurable protein matrices for prolonged neuroblasts patterning and retraction

Abstract

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Keywords

ASJC Scopus subject areas

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