Recombinant virus-mediated transfer of the wild-type p53 gene is a potent therapeutic strategy for human cancer

Toshiyoshi Fujiwara, Shunsuke Kagawa, N. Ogawa, T. Yasuda, N. Tanaka, K. Orita, D. W. Cai, W. W. Zhang, J. A. Roth

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Tumor suppressor p53 gene, which is most commonly mutated in human cancers, plays an important role in the control of cell cycle and the induction of apoptosis (programmed cell death). Transfection of the wild-type p53 gene into tumor cells induced either growth suppression or apoptosis. We have examined the effect of the recombinant retroviral or adenoviral vector expressing the wild-type p53 gene on the tumor cell proliferation as well as on the sensitivity of infected-tumor cells to various anticancer agents. The possible application of recombinant virus-mediated direct in vivo transfer of the wild-type p53 gene to human cancer therapy will be discussed.

Original languageEnglish
Pages (from-to)25-30
Number of pages6
JournalHuman cell : official journal of Human Cell Research Society
Volume9
Issue number1
Publication statusPublished - Mar 1996

Fingerprint

p53 Genes
Viruses
Neoplasms
Apoptosis
Therapeutics
Cell Cycle Checkpoints
Tumor Suppressor Genes
Antineoplastic Agents
Transfection
Cell Death
Cell Proliferation
Growth

ASJC Scopus subject areas

  • Cell Biology
  • Cancer Research

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Recombinant virus-mediated transfer of the wild-type p53 gene is a potent therapeutic strategy for human cancer. / Fujiwara, Toshiyoshi; Kagawa, Shunsuke; Ogawa, N.; Yasuda, T.; Tanaka, N.; Orita, K.; Cai, D. W.; Zhang, W. W.; Roth, J. A.

In: Human cell : official journal of Human Cell Research Society, Vol. 9, No. 1, 03.1996, p. 25-30.

Research output: Contribution to journalArticle

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