Abstract
In the viral reproduction, hepatitis C virus(HCV) produces double-stranded RNA (dsRNA) as a replication intermediate. RIG-I(retinoic acid inducible protein I) recognizes the intracellular HCV dsRNA as a "non self" molecule, and triggers the induction of interferon (IFN)-β and then numerous IFN-stimulated genes(ISGs). On the other hand, one of toll-like receptors, TLR3 also recognizes the extracellular HCV dsRNA, and subsequently triggers the induction of IFN-β and ISGs. We recently reported class A scavenger receptor (MSR1) was required for TLR3-mediated recognition of the extracellular HCV dsRNA. In this review, we summarize current knowledge about RIG-I- and TLR3/MSR1-mediated recognition mechanisms of HCV infection.
| Original language | English |
|---|---|
| Pages (from-to) | 229-233 |
| Number of pages | 5 |
| Journal | Nihon rinsho. Japanese journal of clinical medicine |
| Volume | 73 |
| Issue number | 2 |
| Publication status | Published - Feb 1 2015 |
| Externally published | Yes |
ASJC Scopus subject areas
- Medicine(all)
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Cite this
Dansako, H., & Kato, N. (2015). [Recognition mechanism of hepatitis C viral infection]. Nihon rinsho. Japanese journal of clinical medicine, 73(2), 229-233.