Abstract
A variety of natural products, a valuable source of drug lead compounds, coexist with their stereoisomers as congeners. For pursuing the structural elucidation and the structure–activity relationship study of natural products, it is needed to establish the streamlined synthetic route to supply natural products and their stereoisomers. Divergent pathway is one of the synthetic strategies to deliver more than one target compound. In this digest, selected examples of the stereodivergent approach toward the synthesis of natural products are described. Especially, this digest focuses on common synthetic intermediates and stereodiversification steps from the common intermediates to reach the target compounds.
| Original language | English |
|---|---|
| Pages (from-to) | 955-966 |
| Number of pages | 12 |
| Journal | Tetrahedron Letters |
| Volume | 59 |
| Issue number | 11 |
| DOIs | |
| Publication status | Published - Mar 14 2018 |
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Keywords
- Natural product
- Stereodivergent synthesis
- Stereodiversification
- Stereoisomer
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry
Cite this
Recent topics of the stereodivergent synthesis of natural products. / Takamura, Hiroyoshi.
In: Tetrahedron Letters, Vol. 59, No. 11, 14.03.2018, p. 955-966.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Recent topics of the stereodivergent synthesis of natural products
AU - Takamura, Hiroyoshi
PY - 2018/3/14
Y1 - 2018/3/14
N2 - A variety of natural products, a valuable source of drug lead compounds, coexist with their stereoisomers as congeners. For pursuing the structural elucidation and the structure–activity relationship study of natural products, it is needed to establish the streamlined synthetic route to supply natural products and their stereoisomers. Divergent pathway is one of the synthetic strategies to deliver more than one target compound. In this digest, selected examples of the stereodivergent approach toward the synthesis of natural products are described. Especially, this digest focuses on common synthetic intermediates and stereodiversification steps from the common intermediates to reach the target compounds.
AB - A variety of natural products, a valuable source of drug lead compounds, coexist with their stereoisomers as congeners. For pursuing the structural elucidation and the structure–activity relationship study of natural products, it is needed to establish the streamlined synthetic route to supply natural products and their stereoisomers. Divergent pathway is one of the synthetic strategies to deliver more than one target compound. In this digest, selected examples of the stereodivergent approach toward the synthesis of natural products are described. Especially, this digest focuses on common synthetic intermediates and stereodiversification steps from the common intermediates to reach the target compounds.
KW - Natural product
KW - Stereodivergent synthesis
KW - Stereodiversification
KW - Stereoisomer
UR - http://www.scopus.com/inward/record.url?scp=85042195944&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85042195944&partnerID=8YFLogxK
U2 - 10.1016/j.tetlet.2018.02.004
DO - 10.1016/j.tetlet.2018.02.004
M3 - Review article
VL - 59
SP - 955
EP - 966
JO - Tetrahedron Letters
JF - Tetrahedron Letters
SN - 0040-4039
IS - 11
ER -