Recent topics of the stereodivergent synthesis of natural products

Hiroyoshi Takamura

doi:10.1016/j.tetlet.2018.02.004

Recent topics of the stereodivergent synthesis of natural products

Hiroyoshi Takamura

Research output: Contribution to journal › Review article › peer-review

10 Citations (Scopus)

Abstract

A variety of natural products, a valuable source of drug lead compounds, coexist with their stereoisomers as congeners. For pursuing the structural elucidation and the structure–activity relationship study of natural products, it is needed to establish the streamlined synthetic route to supply natural products and their stereoisomers. Divergent pathway is one of the synthetic strategies to deliver more than one target compound. In this digest, selected examples of the stereodivergent approach toward the synthesis of natural products are described. Especially, this digest focuses on common synthetic intermediates and stereodiversification steps from the common intermediates to reach the target compounds.

Original language	English
Pages (from-to)	955-966
Number of pages	12
Journal	Tetrahedron Letters
Volume	59
Issue number	11
DOIs	https://doi.org/10.1016/j.tetlet.2018.02.004
Publication status	Published - Mar 14 2018

Keywords

Natural product
Stereodivergent synthesis
Stereodiversification
Stereoisomer

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/j.tetlet.2018.02.004

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abstract = "A variety of natural products, a valuable source of drug lead compounds, coexist with their stereoisomers as congeners. For pursuing the structural elucidation and the structure–activity relationship study of natural products, it is needed to establish the streamlined synthetic route to supply natural products and their stereoisomers. Divergent pathway is one of the synthetic strategies to deliver more than one target compound. In this digest, selected examples of the stereodivergent approach toward the synthesis of natural products are described. Especially, this digest focuses on common synthetic intermediates and stereodiversification steps from the common intermediates to reach the target compounds.",

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AB - A variety of natural products, a valuable source of drug lead compounds, coexist with their stereoisomers as congeners. For pursuing the structural elucidation and the structure–activity relationship study of natural products, it is needed to establish the streamlined synthetic route to supply natural products and their stereoisomers. Divergent pathway is one of the synthetic strategies to deliver more than one target compound. In this digest, selected examples of the stereodivergent approach toward the synthesis of natural products are described. Especially, this digest focuses on common synthetic intermediates and stereodiversification steps from the common intermediates to reach the target compounds.

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KW - Stereodiversification

KW - Stereoisomer

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Recent topics of the stereodivergent synthesis of natural products

Abstract

Keywords

ASJC Scopus subject areas

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