Recent topics of the stereodivergent synthesis of natural products

Research output: Contribution to journalReview article

2 Citations (Scopus)

Abstract

A variety of natural products, a valuable source of drug lead compounds, coexist with their stereoisomers as congeners. For pursuing the structural elucidation and the structure–activity relationship study of natural products, it is needed to establish the streamlined synthetic route to supply natural products and their stereoisomers. Divergent pathway is one of the synthetic strategies to deliver more than one target compound. In this digest, selected examples of the stereodivergent approach toward the synthesis of natural products are described. Especially, this digest focuses on common synthetic intermediates and stereodiversification steps from the common intermediates to reach the target compounds.

Original languageEnglish
Pages (from-to)955-966
Number of pages12
JournalTetrahedron Letters
Volume59
Issue number11
DOIs
Publication statusPublished - Mar 14 2018

Fingerprint

Biological Products
Stereoisomerism
Lead compounds
Pharmaceutical Preparations

Keywords

  • Natural product
  • Stereodivergent synthesis
  • Stereodiversification
  • Stereoisomer

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

Cite this

Recent topics of the stereodivergent synthesis of natural products. / Takamura, Hiroyoshi.

In: Tetrahedron Letters, Vol. 59, No. 11, 14.03.2018, p. 955-966.

Research output: Contribution to journalReview article

@article{e93246d13d1f43caa396716d4eebb302,
title = "Recent topics of the stereodivergent synthesis of natural products",
abstract = "A variety of natural products, a valuable source of drug lead compounds, coexist with their stereoisomers as congeners. For pursuing the structural elucidation and the structure–activity relationship study of natural products, it is needed to establish the streamlined synthetic route to supply natural products and their stereoisomers. Divergent pathway is one of the synthetic strategies to deliver more than one target compound. In this digest, selected examples of the stereodivergent approach toward the synthesis of natural products are described. Especially, this digest focuses on common synthetic intermediates and stereodiversification steps from the common intermediates to reach the target compounds.",
keywords = "Natural product, Stereodivergent synthesis, Stereodiversification, Stereoisomer",
author = "Hiroyoshi Takamura",
year = "2018",
month = "3",
day = "14",
doi = "10.1016/j.tetlet.2018.02.004",
language = "English",
volume = "59",
pages = "955--966",
journal = "Tetrahedron Letters",
issn = "0040-4039",
publisher = "Elsevier Limited",
number = "11",

}

TY - JOUR

T1 - Recent topics of the stereodivergent synthesis of natural products

AU - Takamura, Hiroyoshi

PY - 2018/3/14

Y1 - 2018/3/14

N2 - A variety of natural products, a valuable source of drug lead compounds, coexist with their stereoisomers as congeners. For pursuing the structural elucidation and the structure–activity relationship study of natural products, it is needed to establish the streamlined synthetic route to supply natural products and their stereoisomers. Divergent pathway is one of the synthetic strategies to deliver more than one target compound. In this digest, selected examples of the stereodivergent approach toward the synthesis of natural products are described. Especially, this digest focuses on common synthetic intermediates and stereodiversification steps from the common intermediates to reach the target compounds.

AB - A variety of natural products, a valuable source of drug lead compounds, coexist with their stereoisomers as congeners. For pursuing the structural elucidation and the structure–activity relationship study of natural products, it is needed to establish the streamlined synthetic route to supply natural products and their stereoisomers. Divergent pathway is one of the synthetic strategies to deliver more than one target compound. In this digest, selected examples of the stereodivergent approach toward the synthesis of natural products are described. Especially, this digest focuses on common synthetic intermediates and stereodiversification steps from the common intermediates to reach the target compounds.

KW - Natural product

KW - Stereodivergent synthesis

KW - Stereodiversification

KW - Stereoisomer

UR - http://www.scopus.com/inward/record.url?scp=85042195944&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85042195944&partnerID=8YFLogxK

U2 - 10.1016/j.tetlet.2018.02.004

DO - 10.1016/j.tetlet.2018.02.004

M3 - Review article

VL - 59

SP - 955

EP - 966

JO - Tetrahedron Letters

JF - Tetrahedron Letters

SN - 0040-4039

IS - 11

ER -