Abstract
Using cDNA expression array and tissue microarray, we comprehensively and systematically analyzed the expression profile to investigate the lymphomagenesis. We detected the significant decrease of hematopoietic cell specific protein-tyrosine phosphatase SHP1 gene expression in various malignant lymphomas and leukemias. High-frequent silencing of the SHP1 gene by promoter methylation was detected in various kinds of leukemias and lymphomas as well as in many hematopoietic cell lines. The promoter methylation of the SHP1 gene was significantly correlated with the clinical stage. Loss of heterozygosity with microsatellite markers around the SHP1 gene was detected in 79% of informative ALL cases. These results suggest that loss of functional SHP1 is closely associated with the pathogenesis of leukemias/lymphomas.
| Original language | English |
|---|---|
| Pages (from-to) | 2025-2032 |
| Number of pages | 8 |
| Journal | Nihon rinsho. Japanese journal of clinical medicine |
| Volume | 61 |
| Issue number | 11 |
| Publication status | Published - 2003 |
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Recent progress in the protein-tyrosine phosphatase SHP1 gene : the significant correlation of the SHP1 gene silencing with the onset of lymphomas/leukemias. / Oka, Takashi; Oouchida, Mamoru.
In: Nihon rinsho. Japanese journal of clinical medicine, Vol. 61, No. 11, 2003, p. 2025-2032.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Recent progress in the protein-tyrosine phosphatase SHP1 gene
T2 - the significant correlation of the SHP1 gene silencing with the onset of lymphomas/leukemias
AU - Oka, Takashi
AU - Oouchida, Mamoru
PY - 2003
Y1 - 2003
N2 - Using cDNA expression array and tissue microarray, we comprehensively and systematically analyzed the expression profile to investigate the lymphomagenesis. We detected the significant decrease of hematopoietic cell specific protein-tyrosine phosphatase SHP1 gene expression in various malignant lymphomas and leukemias. High-frequent silencing of the SHP1 gene by promoter methylation was detected in various kinds of leukemias and lymphomas as well as in many hematopoietic cell lines. The promoter methylation of the SHP1 gene was significantly correlated with the clinical stage. Loss of heterozygosity with microsatellite markers around the SHP1 gene was detected in 79% of informative ALL cases. These results suggest that loss of functional SHP1 is closely associated with the pathogenesis of leukemias/lymphomas.
AB - Using cDNA expression array and tissue microarray, we comprehensively and systematically analyzed the expression profile to investigate the lymphomagenesis. We detected the significant decrease of hematopoietic cell specific protein-tyrosine phosphatase SHP1 gene expression in various malignant lymphomas and leukemias. High-frequent silencing of the SHP1 gene by promoter methylation was detected in various kinds of leukemias and lymphomas as well as in many hematopoietic cell lines. The promoter methylation of the SHP1 gene was significantly correlated with the clinical stage. Loss of heterozygosity with microsatellite markers around the SHP1 gene was detected in 79% of informative ALL cases. These results suggest that loss of functional SHP1 is closely associated with the pathogenesis of leukemias/lymphomas.
UR - http://www.scopus.com/inward/record.url?scp=1542704895&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=1542704895&partnerID=8YFLogxK
M3 - Article
C2 - 14619449
AN - SCOPUS:1542704895
VL - 61
SP - 2025
EP - 2032
JO - Nippon rinsho. Japanese journal of clinical medicine
JF - Nippon rinsho. Japanese journal of clinical medicine
SN - 0047-1852
IS - 11
ER -