Recent progress in cell reprogramming technology for cell transplantation therapy

Toru Yamashita, Koji Abe

Research output: Contribution to journalReview articlepeer-review

1 Citation (Scopus)


The discovery of induced pluripotent stem (iPS) cells opened the gate for reprogramming technology with which we can change the cell fate through overexpression of master transcriptional factors. Now we can prepare various kinds of neuronal cells directly induced from somatic cells. It has been reported that overexpression of a neuron-specific transcriptional factors might change the cell fate of endogenous astroglia to neuronal cells in vivo. In addition, some research groups demonstrated that chemical compound can induce chemical-induced neuronal cells, without transcriptional factors overexpression. In this review, we briefly review recent progress in the induced neuronal (iN) cells, and discuss the possibility of application for cell transplantation therapy.

Original languageEnglish
Pages (from-to)97-101
Number of pages5
Journalneurologia medico-chirurgica
Issue number3
Publication statusPublished - Mar 15 2016


  • Chemical-induced neuronal cells
  • In vivo direct reprogramming
  • Induced neuronal cells
  • Induced pluripotent stem cells
  • Stroke

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology


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