Recent patents of TGF-beta family and VEGF associated with ovarian follicular development in mammals.

Takashi Shimizu, Yasuyuki Abe, Takuya Wakai, Yumi Hoshino, Akio Miyamoto, Eimei Sato

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

In mammalian ovary, follicular development in mammals is regulated by the complex process including endocrine, paracrine and autocrine. During the last decade, the role of growth factors in ovarian folliculogenesis has been extensively studied in mammals. In particular, a growing body of evidence indicates that the vascular endothelial growth factor (VEGF) system plays a key role in follicular development and atresia in the woman, rodents and domestic animal species. More recently, the bone morphogenetic protein (BMP) and growth differentiation factor (GDF) that belong to TGF-beta family have been shown to be involved in the regulation of follicle growth. In this paper, we will essentially consider the role of these growth factor systems in mammalian ovary. Moreover, we will review recent patents associated with ovarian follicular development in mammals.

Original languageEnglish
Pages (from-to)195-199
Number of pages5
JournalRecent patents on DNA & gene sequences
Volume1
Issue number3
Publication statusPublished - 2007
Externally publishedYes

Fingerprint

Patents
Transforming Growth Factor beta
Vascular Endothelial Growth Factor A
Mammals
Ovary
Intercellular Signaling Peptides and Proteins
Follicular Atresia
Growth Differentiation Factors
Bone Morphogenetic Proteins
Domestic Animals
Rodentia
Growth

ASJC Scopus subject areas

  • Molecular Biology
  • Biotechnology
  • Genetics(clinical)

Cite this

Recent patents of TGF-beta family and VEGF associated with ovarian follicular development in mammals. / Shimizu, Takashi; Abe, Yasuyuki; Wakai, Takuya; Hoshino, Yumi; Miyamoto, Akio; Sato, Eimei.

In: Recent patents on DNA & gene sequences, Vol. 1, No. 3, 2007, p. 195-199.

Research output: Contribution to journalArticle

Shimizu, Takashi ; Abe, Yasuyuki ; Wakai, Takuya ; Hoshino, Yumi ; Miyamoto, Akio ; Sato, Eimei. / Recent patents of TGF-beta family and VEGF associated with ovarian follicular development in mammals. In: Recent patents on DNA & gene sequences. 2007 ; Vol. 1, No. 3. pp. 195-199.
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