Recent Advances in Transition-metal-catalyzed C−C Bond Formation via C(sp2)−F Bond Cleavage

Liyan Fu, Qiang Chen, Yasushi Nishihara

    Research output: Contribution to journalArticlepeer-review

    1 Citation (Scopus)


    The activation of a carbon-fluorine bond is one of the most challenging topics in modern synthetic organic chemistry due to their low reactivity compared to other carbon-halogen bonds. In this review, we present the recent developments since 2015 on cross-coupling reactions that form C−C bonds via cleavage of C(sp2)−F bonds. Not only the conventional activation of C(sp2)−F bonds, but also decarbonylative or carbonyl-retentive cleavage of C(acyl)−F bonds will be introduced. This paper mainly describes new protocols for the formation of C(sp2)−C(sp3), C(sp2)−C(sp2), and C(sp2)−C(sp) bonds via transition-metal-catalyzed cleavage of C(sp2)−F bonds.

    Original languageEnglish
    JournalChemical Record
    Publication statusAccepted/In press - 2021


    • coupling reaction
    • C−C bond formation
    • C−F bond activation
    • decarbonylation
    • transition metal

    ASJC Scopus subject areas

    • Chemistry(all)
    • Biochemistry
    • Chemical Engineering(all)
    • Materials Chemistry


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