Real-time determination of the cell-cycle position of individual cells within live tumors using FUCCI cell-cycle imaging

Shuya Yano, Robert M. Hoffman

Research output: Contribution to journalReview articlepeer-review

12 Citations (Scopus)

Abstract

Most cytotoxic agents have limited efficacy for solid cancers. Cell-cycle phase analysis at the single-cell level in solid tumors has shown that the majority of cancer cells in tumors is not cycling and is therefore resistant to cytotoxic chemotherapy. Intravital cell-cycle imaging within tumors demonstrated the cell-cycle position and distribution of cancer cells within a tumor, and cell-cycle dynamics during chemotherapy. Understanding cell-cycle dynamics within tumors should provide important insights into novel treatment strategies.

Original languageEnglish
Article number168
JournalCells
Volume7
Issue number10
DOIs
Publication statusPublished - Oct 14 2018
Externally publishedYes

Keywords

  • Cell cycle
  • Fluorescent proteins
  • FUCCI
  • Imaging

ASJC Scopus subject areas

  • Medicine(all)

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