Reactivation of human herpes virus-6 in the renal tissue of a patient with drug-induced hypersensitivity syndrome/drug rash with eosinophilia and systemic symptoms (DIHS/DRESS)

Hideharu Hagiya; Masaya Iwamuro; Takehiro Tanaka; Kou Hasegawa; Yoshihisa Hanayama; Maya Kimura; Fumio Otsuka

doi:10.2169/internalmedicine.55.6287

Reactivation of human herpes virus-6 in the renal tissue of a patient with drug-induced hypersensitivity syndrome/drug rash with eosinophilia and systemic symptoms (DIHS/DRESS)

Hideharu Hagiya, Masaya Iwamuro, Takehiro Tanaka, Kou Hasegawa, Yoshihisa Hanayama, Maya Kimura, Fumio Otsuka

Research output: Contribution to journal › Article

2 Citations (Scopus)

Abstract

A 74-year-old man who had been administered trimethoprim-sulfamethoxazole for three weeks suffered from drug-induced hypersensitivity syndrome/drug rash with eosinophilia and systemic symptoms (DIHS/DRESS). In the early stage of the clinical course, he developed renal dysfunction. A renal biopsy showed granulomatous tubulointerstitial nephritis accompanying the proliferation of human herpes virus (HHV)-6 in tubular epithelial cells. With corticosteroid therapy, the systemic rash and renal function gradually improved. The present patient is the second case of DIHS/DRESS demonstrating a possible reactivation of HHV-6 in the renal tissue. The clinical role of viral reactivation in DIHS/DRESS must be further elucidated.

Original language	English
Pages (from-to)	1769-1774
Number of pages	6
Journal	Internal Medicine
Volume	55
Issue number	13
DOIs	https://doi.org/10.2169/internalmedicine.55.6287
Publication status	Published - 2016

Fingerprint

Keywords

Drug rash with eosinophilia and systemic symptoms (DRESS)
Drug-induced hypersensitivity syndrome (DIHS)
Eosinophilia
Human herpes virus 6 (HHV-6)
Reactivation

ASJC Scopus subject areas

Internal Medicine

Cite this

Hagiya, H., Iwamuro, M., Tanaka, T., Hasegawa, K., Hanayama, Y., Kimura, M., & Otsuka, F. (2016). Reactivation of human herpes virus-6 in the renal tissue of a patient with drug-induced hypersensitivity syndrome/drug rash with eosinophilia and systemic symptoms (DIHS/DRESS). Internal Medicine, 55(13), 1769-1774. https://doi.org/10.2169/internalmedicine.55.6287

Reactivation of human herpes virus-6 in the renal tissue of a patient with drug-induced hypersensitivity syndrome/drug rash with eosinophilia and systemic symptoms (DIHS/DRESS). / Hagiya, Hideharu ; Iwamuro, Masaya ; Tanaka, Takehiro ; Hasegawa, Kou ; Hanayama, Yoshihisa; Kimura, Maya; Otsuka, Fumio.

In: Internal Medicine, Vol. 55, No. 13, 2016, p. 1769-1774.

Research output: Contribution to journal › Article

Hagiya, Hideharu ; Iwamuro, Masaya ; Tanaka, Takehiro ; Hasegawa, Kou ; Hanayama, Yoshihisa ; Kimura, Maya ; Otsuka, Fumio. / Reactivation of human herpes virus-6 in the renal tissue of a patient with drug-induced hypersensitivity syndrome/drug rash with eosinophilia and systemic symptoms (DIHS/DRESS). In: Internal Medicine. 2016 ; Vol. 55, No. 13. pp. 1769-1774.

@article{b618304d218c4adc820bc8a751144e2d,

title = "Reactivation of human herpes virus-6 in the renal tissue of a patient with drug-induced hypersensitivity syndrome/drug rash with eosinophilia and systemic symptoms (DIHS/DRESS)",

abstract = "A 74-year-old man who had been administered trimethoprim-sulfamethoxazole for three weeks suffered from drug-induced hypersensitivity syndrome/drug rash with eosinophilia and systemic symptoms (DIHS/DRESS). In the early stage of the clinical course, he developed renal dysfunction. A renal biopsy showed granulomatous tubulointerstitial nephritis accompanying the proliferation of human herpes virus (HHV)-6 in tubular epithelial cells. With corticosteroid therapy, the systemic rash and renal function gradually improved. The present patient is the second case of DIHS/DRESS demonstrating a possible reactivation of HHV-6 in the renal tissue. The clinical role of viral reactivation in DIHS/DRESS must be further elucidated.",

keywords = "Drug rash with eosinophilia and systemic symptoms (DRESS), Drug-induced hypersensitivity syndrome (DIHS), Eosinophilia, Human herpes virus 6 (HHV-6), Reactivation",

author = "Hideharu Hagiya and Masaya Iwamuro and Takehiro Tanaka and Kou Hasegawa and Yoshihisa Hanayama and Maya Kimura and Fumio Otsuka",

year = "2016",

doi = "10.2169/internalmedicine.55.6287",

language = "English",

volume = "55",

pages = "1769--1774",

journal = "Internal Medicine",

issn = "0918-2918",

publisher = "Japanese Society of Internal Medicine",

number = "13",

}

TY - JOUR

T1 - Reactivation of human herpes virus-6 in the renal tissue of a patient with drug-induced hypersensitivity syndrome/drug rash with eosinophilia and systemic symptoms (DIHS/DRESS)

AU - Hagiya, Hideharu

AU - Iwamuro, Masaya

AU - Tanaka, Takehiro

AU - Hasegawa, Kou

AU - Hanayama, Yoshihisa

AU - Kimura, Maya

AU - Otsuka, Fumio

PY - 2016

Y1 - 2016

N2 - A 74-year-old man who had been administered trimethoprim-sulfamethoxazole for three weeks suffered from drug-induced hypersensitivity syndrome/drug rash with eosinophilia and systemic symptoms (DIHS/DRESS). In the early stage of the clinical course, he developed renal dysfunction. A renal biopsy showed granulomatous tubulointerstitial nephritis accompanying the proliferation of human herpes virus (HHV)-6 in tubular epithelial cells. With corticosteroid therapy, the systemic rash and renal function gradually improved. The present patient is the second case of DIHS/DRESS demonstrating a possible reactivation of HHV-6 in the renal tissue. The clinical role of viral reactivation in DIHS/DRESS must be further elucidated.

AB - A 74-year-old man who had been administered trimethoprim-sulfamethoxazole for three weeks suffered from drug-induced hypersensitivity syndrome/drug rash with eosinophilia and systemic symptoms (DIHS/DRESS). In the early stage of the clinical course, he developed renal dysfunction. A renal biopsy showed granulomatous tubulointerstitial nephritis accompanying the proliferation of human herpes virus (HHV)-6 in tubular epithelial cells. With corticosteroid therapy, the systemic rash and renal function gradually improved. The present patient is the second case of DIHS/DRESS demonstrating a possible reactivation of HHV-6 in the renal tissue. The clinical role of viral reactivation in DIHS/DRESS must be further elucidated.

KW - Drug rash with eosinophilia and systemic symptoms (DRESS)

KW - Drug-induced hypersensitivity syndrome (DIHS)

KW - Eosinophilia

KW - Human herpes virus 6 (HHV-6)

KW - Reactivation

UR - http://www.scopus.com/inward/record.url?scp=84976530068&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84976530068&partnerID=8YFLogxK

U2 - 10.2169/internalmedicine.55.6287

DO - 10.2169/internalmedicine.55.6287

M3 - Article

C2 - 27374681

AN - SCOPUS:84976530068

VL - 55

SP - 1769

EP - 1774

JO - Internal Medicine

JF - Internal Medicine

SN - 0918-2918

IS - 13

ER -

Access to Document

10.2169/internalmedicine.55.6287