Reactivation of human herpes virus-6 in the renal tissue of a patient with drug-induced hypersensitivity syndrome/drug rash with eosinophilia and systemic symptoms (DIHS/DRESS)

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Abstract

A 74-year-old man who had been administered trimethoprim-sulfamethoxazole for three weeks suffered from drug-induced hypersensitivity syndrome/drug rash with eosinophilia and systemic symptoms (DIHS/DRESS). In the early stage of the clinical course, he developed renal dysfunction. A renal biopsy showed granulomatous tubulointerstitial nephritis accompanying the proliferation of human herpes virus (HHV)-6 in tubular epithelial cells. With corticosteroid therapy, the systemic rash and renal function gradually improved. The present patient is the second case of DIHS/DRESS demonstrating a possible reactivation of HHV-6 in the renal tissue. The clinical role of viral reactivation in DIHS/DRESS must be further elucidated.

Original languageEnglish
Pages (from-to)1769-1774
Number of pages6
JournalInternal Medicine
Volume55
Issue number13
DOIs
Publication statusPublished - 2016

Keywords

  • Drug rash with eosinophilia and systemic symptoms (DRESS)
  • Drug-induced hypersensitivity syndrome (DIHS)
  • Eosinophilia
  • Human herpes virus 6 (HHV-6)
  • Reactivation

ASJC Scopus subject areas

  • Internal Medicine

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