Reactivation of human herpes virus-6 in the renal tissue of a patient with drug-induced hypersensitivity syndrome/drug rash with eosinophilia and systemic symptoms (DIHS/DRESS)

Hideharu Hagiya; Masaya Iwamuro; Takehiro Tanaka; Kou Hasegawa; Yoshihisa Hanayama; Maya Kimura; Fumio Otsuka

doi:10.2169/internalmedicine.55.6287

Reactivation of human herpes virus-6 in the renal tissue of a patient with drug-induced hypersensitivity syndrome/drug rash with eosinophilia and systemic symptoms (DIHS/DRESS)

Hideharu Hagiya, Masaya Iwamuro, Takehiro Tanaka, Kou Hasegawa, Yoshihisa Hanayama, Maya Kimura, Fumio Otsuka

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

A 74-year-old man who had been administered trimethoprim-sulfamethoxazole for three weeks suffered from drug-induced hypersensitivity syndrome/drug rash with eosinophilia and systemic symptoms (DIHS/DRESS). In the early stage of the clinical course, he developed renal dysfunction. A renal biopsy showed granulomatous tubulointerstitial nephritis accompanying the proliferation of human herpes virus (HHV)-6 in tubular epithelial cells. With corticosteroid therapy, the systemic rash and renal function gradually improved. The present patient is the second case of DIHS/DRESS demonstrating a possible reactivation of HHV-6 in the renal tissue. The clinical role of viral reactivation in DIHS/DRESS must be further elucidated.

Original language	English
Pages (from-to)	1769-1774
Number of pages	6
Journal	Internal Medicine
Volume	55
Issue number	13
DOIs	https://doi.org/10.2169/internalmedicine.55.6287
Publication status	Published - 2016

Keywords

Drug rash with eosinophilia and systemic symptoms (DRESS)
Drug-induced hypersensitivity syndrome (DIHS)
Eosinophilia
Human herpes virus 6 (HHV-6)
Reactivation

ASJC Scopus subject areas

Internal Medicine

Access to Document

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Reactivation of human herpes virus-6 in the renal tissue of a patient with drug-induced hypersensitivity syndrome/drug rash with eosinophilia and systemic symptoms (DIHS/DRESS). / Hagiya, Hideharu ; Iwamuro, Masaya ; Tanaka, Takehiro ; Hasegawa, Kou ; Hanayama, Yoshihisa; Kimura, Maya; Otsuka, Fumio.

In: Internal Medicine, Vol. 55, No. 13, 2016, p. 1769-1774.

Research output: Contribution to journal › Article › peer-review

Hagiya, Hideharu ; Iwamuro, Masaya ; Tanaka, Takehiro ; Hasegawa, Kou ; Hanayama, Yoshihisa ; Kimura, Maya ; Otsuka, Fumio. / Reactivation of human herpes virus-6 in the renal tissue of a patient with drug-induced hypersensitivity syndrome/drug rash with eosinophilia and systemic symptoms (DIHS/DRESS). In: Internal Medicine. 2016 ; Vol. 55, No. 13. pp. 1769-1774.

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abstract = "A 74-year-old man who had been administered trimethoprim-sulfamethoxazole for three weeks suffered from drug-induced hypersensitivity syndrome/drug rash with eosinophilia and systemic symptoms (DIHS/DRESS). In the early stage of the clinical course, he developed renal dysfunction. A renal biopsy showed granulomatous tubulointerstitial nephritis accompanying the proliferation of human herpes virus (HHV)-6 in tubular epithelial cells. With corticosteroid therapy, the systemic rash and renal function gradually improved. The present patient is the second case of DIHS/DRESS demonstrating a possible reactivation of HHV-6 in the renal tissue. The clinical role of viral reactivation in DIHS/DRESS must be further elucidated.",

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AU - Tanaka, Takehiro

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