Abstract
A 74-year-old man who had been administered trimethoprim-sulfamethoxazole for three weeks suffered from drug-induced hypersensitivity syndrome/drug rash with eosinophilia and systemic symptoms (DIHS/DRESS). In the early stage of the clinical course, he developed renal dysfunction. A renal biopsy showed granulomatous tubulointerstitial nephritis accompanying the proliferation of human herpes virus (HHV)-6 in tubular epithelial cells. With corticosteroid therapy, the systemic rash and renal function gradually improved. The present patient is the second case of DIHS/DRESS demonstrating a possible reactivation of HHV-6 in the renal tissue. The clinical role of viral reactivation in DIHS/DRESS must be further elucidated.
| Original language | English |
|---|---|
| Pages (from-to) | 1769-1774 |
| Number of pages | 6 |
| Journal | Internal Medicine |
| Volume | 55 |
| Issue number | 13 |
| DOIs | |
| Publication status | Published - 2016 |
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Keywords
- Drug rash with eosinophilia and systemic symptoms (DRESS)
- Drug-induced hypersensitivity syndrome (DIHS)
- Eosinophilia
- Human herpes virus 6 (HHV-6)
- Reactivation
ASJC Scopus subject areas
- Internal Medicine
Cite this
Reactivation of human herpes virus-6 in the renal tissue of a patient with drug-induced hypersensitivity syndrome/drug rash with eosinophilia and systemic symptoms (DIHS/DRESS). / Hagiya, Hideharu; Iwamuro, Masaya; Tanaka, Takehiro; Hasegawa, Kou; Hanayama, Yoshihisa; Kimura, Maya; Otsuka, Fumio.
In: Internal Medicine, Vol. 55, No. 13, 2016, p. 1769-1774.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Reactivation of human herpes virus-6 in the renal tissue of a patient with drug-induced hypersensitivity syndrome/drug rash with eosinophilia and systemic symptoms (DIHS/DRESS)
AU - Hagiya, Hideharu
AU - Iwamuro, Masaya
AU - Tanaka, Takehiro
AU - Hasegawa, Kou
AU - Hanayama, Yoshihisa
AU - Kimura, Maya
AU - Otsuka, Fumio
PY - 2016
Y1 - 2016
N2 - A 74-year-old man who had been administered trimethoprim-sulfamethoxazole for three weeks suffered from drug-induced hypersensitivity syndrome/drug rash with eosinophilia and systemic symptoms (DIHS/DRESS). In the early stage of the clinical course, he developed renal dysfunction. A renal biopsy showed granulomatous tubulointerstitial nephritis accompanying the proliferation of human herpes virus (HHV)-6 in tubular epithelial cells. With corticosteroid therapy, the systemic rash and renal function gradually improved. The present patient is the second case of DIHS/DRESS demonstrating a possible reactivation of HHV-6 in the renal tissue. The clinical role of viral reactivation in DIHS/DRESS must be further elucidated.
AB - A 74-year-old man who had been administered trimethoprim-sulfamethoxazole for three weeks suffered from drug-induced hypersensitivity syndrome/drug rash with eosinophilia and systemic symptoms (DIHS/DRESS). In the early stage of the clinical course, he developed renal dysfunction. A renal biopsy showed granulomatous tubulointerstitial nephritis accompanying the proliferation of human herpes virus (HHV)-6 in tubular epithelial cells. With corticosteroid therapy, the systemic rash and renal function gradually improved. The present patient is the second case of DIHS/DRESS demonstrating a possible reactivation of HHV-6 in the renal tissue. The clinical role of viral reactivation in DIHS/DRESS must be further elucidated.
KW - Drug rash with eosinophilia and systemic symptoms (DRESS)
KW - Drug-induced hypersensitivity syndrome (DIHS)
KW - Eosinophilia
KW - Human herpes virus 6 (HHV-6)
KW - Reactivation
UR - http://www.scopus.com/inward/record.url?scp=84976530068&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84976530068&partnerID=8YFLogxK
U2 - 10.2169/internalmedicine.55.6287
DO - 10.2169/internalmedicine.55.6287
M3 - Article
C2 - 27374681
AN - SCOPUS:84976530068
VL - 55
SP - 1769
EP - 1774
JO - Internal Medicine
JF - Internal Medicine
SN - 0918-2918
IS - 13
ER -