Reaction of spiro [piperidine-4,2′-(1′,2′,3′,4′-tetrahydroquinazolin)]-4′-ones with acetic anhydride

Masatoshi Yamato, Yasuo Takeuchi, Yuji Ikeda

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The tetrahydro derivative (5a) and its aza derivative (5b) of antitumor active amsacrine were prepared. The key synthetic intermediate (3a) was simply prepared by rearrangement of spiro-compound (2a) by heating with acetic anhydride and pyridine. On the other hand, another key intermediate (3b) was obtained only during moderated reaction conditions, and the ring opening products (6b,b′ and 8b,b′) were obtained under the usal conditions.

Original languageEnglish
Pages (from-to)191-197
Number of pages7
JournalHeterocycles
Volume26
Issue number1
Publication statusPublished - Jan 1 1987

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Spiro Compounds
Amsacrine
Heating
Derivatives
piperidine
pyridine
acetic anhydride

ASJC Scopus subject areas

  • Organic Chemistry

Cite this

Reaction of spiro [piperidine-4,2′-(1′,2′,3′,4′-tetrahydroquinazolin)]-4′-ones with acetic anhydride. / Yamato, Masatoshi; Takeuchi, Yasuo; Ikeda, Yuji.

In: Heterocycles, Vol. 26, No. 1, 01.01.1987, p. 191-197.

Research output: Contribution to journalArticle

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