Reaction of an electrogenerated 'iminium cation pool' with organometallic reagents. Direct oxidative α-alkylation and -arylation of amine derivatives

Seiji Suga, Masayuki Okajima, Jun ichi Yoshida

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We have developed an efficient direct oxidative α-alkylation and -arylation of carbamates based on the 'cation pool' method. Grignard reagents, organozinc compounds, and organoaluminum compounds are effective as carbon nucleophiles toward iminium cation pools generated by low temperature electrolysis of carbamates.

Original languageEnglish
Pages (from-to)2173-2176
Number of pages4
JournalTetrahedron Letters
Issue number11
Publication statusPublished - Mar 11 2001
Externally publishedYes



  • Carbon-carbon bond formation
  • Cation pool
  • Electrochemical oxidation
  • Grignard reagents
  • Iminium cation

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

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