Rational design of gold nanoparticles functionalized with carboranes for application in Boron Neutron Capture Therapy

Laura Ciani, Silva Bortolussi, Ian Postuma, Laura Cansolino, Cinzia Ferrari, Luigi Panza, Saverio Altieri, Sandra Ristori

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)

Abstract

In this paper we propose a bottom-up approach to obtain new boron carriers built with ortho-carborane functionalized gold nanoparticles (GNPs) for applications in Boron Neutron Capture Therapy. The interaction between carboranes and the gold surface was assured by one or two SH-groups directly linked to the boron atoms of the B10C2 cage. This allowed obtaining stable, nontoxic systems, though optimal biological performance was hampered by low solubility in aqueous media. To improve cell uptake, the hydrophilic character of carborane functionalized GNPs was enhanced by further coverage with an appropriately tailored diblock copolymer (PEO-b-PCL). This polymer also contained pendant carboranes to provide anchoring to the pre-functionalized GNPs. In vitro tests, carried out on osteosarcoma cells, showed that the final vectors possessed excellent biocompatibility joint to the capacity of concentrating boron atoms in the target, which is encouraging evidenced to pursue applications in vivo.

Original languageEnglish
Pages (from-to)340-346
Number of pages7
JournalInternational Journal of Pharmaceutics
Volume458
Issue number2
DOIs
Publication statusPublished - 2013
Externally publishedYes

Keywords

  • BNCT
  • Carborane delivery
  • Gold nanoparticles
  • Osteosarcoma

ASJC Scopus subject areas

  • Pharmaceutical Science

Fingerprint

Dive into the research topics of 'Rational design of gold nanoparticles functionalized with carboranes for application in Boron Neutron Capture Therapy'. Together they form a unique fingerprint.

Cite this