Rational control of enantioselectivity of lipase by site-directed mutagenesis based on the mechanism

Tadashi Ema, Toshiyuki Fujii, Misa Ozaki, Toshinobu Korenaga, Takashi Sakai

Research output: Contribution to journalArticlepeer-review

31 Citations (Scopus)

Abstract

The enantioselectivity of a Burkholderia cepacia lipase toward secondary alcohols could be both increased and decreased rationally by introducing only a single mutation on the basis of the mechanism proposed previously.

Original languageEnglish
Pages (from-to)4650-4651
Number of pages2
JournalChemical Communications
Issue number37
DOIs
Publication statusPublished - Oct 7 2005

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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