Ratio of platelet reduction is an early predictive factor for the effectiveness of leukocytapheresis for ulcerative colitis patients

Koji Takemoto, Motoaki Kuriyama, Jun Kato, Hideyuki Suzuki, Shin Ishikawa, Sakiko Hiraoka, Kazuhide Yamamoto

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Leukocytapheresis is effective for ulcerative colitis (UC), and both peripheral leukocyte and platelet counts decrease during apheresis. While leukocyte counts increase and overshoot after finishing the apheresis procedure, platelet reduction continues even after apheresis. The aim of this study is to elucidate the impact of the overshoot of leukocyte and continuous platelet reduction on the efficacy of leukocytapheresis for UC. Leukocyte and platelet counts before and one hour after each leukocytapheresis session of 43 UC cases were examined (31 entered remission, but 12 did not). The correlation between the efficacy of leukocytapheresis and leukocyte overshoot or platelet reduction was examined. The average increase ratio of leukocytes in the initial five sessions of the responders was not significantly different from that of the non-responders (95% vs. 92%, P = 0.28). In contrast, the average decrease ratio of platelets in the initial five sessions of the responders was significantly higher than that of the non-responders (34% vs. 27%, P = 0.0041). Moreover, the platelet reduction at the third and fourth apheresis sessions in the responders was remarkably greater than that in the non-responders (33% vs. 20%, P = 0.0018). The efficiency of platelet reduction could be a predictive factor for the efficacy of leukocytapheresis.

Original languageEnglish
Pages (from-to)6-13
Number of pages8
JournalTherapeutic Apheresis and Dialysis
Volume13
Issue number1
DOIs
Publication statusPublished - Feb 2009

Keywords

  • Leukocytapheresis
  • Platelet removal
  • Ulcerative colitis

ASJC Scopus subject areas

  • Hematology
  • Nephrology

Fingerprint Dive into the research topics of 'Ratio of platelet reduction is an early predictive factor for the effectiveness of leukocytapheresis for ulcerative colitis patients'. Together they form a unique fingerprint.

  • Cite this