(Chemical Equation Presented) Neighboring-group participation of an acyl protecting group efficiently promotes the Brønsted acid-catalyzed dehydrative cyclization of 1,3,5-triketones to γ-pyrones, whereas a bulky silyloxy group in the β-position retards the cyclization. This reaction provides an efficient synthetic route for a common intermediate for the synthesis of γ-pyrone-containing bioactive natural products.
ASJC Scopus subject areas
- Organic Chemistry
- Physical and Theoretical Chemistry
- Molecular Medicine