Rapid response of striatal muscarinic M1-receptor mRNA to muscarinic cholinergic agents in rat brain

Hsi hsien Chou, Norio Ogawa, Masato Asanuma, Hiroshi Hirata, Yoichi Kondo, Akitane Mori

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The effects of a single administration of muscarinic cholinergic agents on the level of muscarinic M1-receptor messenger RNA (M1-R mRNA) in the rat striatum were studied. Carbachol increased the M1-R mRNA expression rapidly and transiently, while trihexyphenidyl decreased it. These results suggest that muscarinic cholinergic agents participate in the positive regulation of muscarinic receptor mRNA in the early stage after treatment, contrary to the negative regulation in the chronic stage.

Original languageEnglish
Pages (from-to)211-214
Number of pages4
JournalMolecular Brain Research
Volume19
Issue number3
DOIs
Publication statusPublished - Aug 1993

Keywords

  • Carbachol
  • Muscarinic M receptor
  • Positive regulation
  • Rapid regulation
  • Rat striatum
  • Trihexyphenidyl
  • mRNA

ASJC Scopus subject areas

  • Molecular Biology
  • Cellular and Molecular Neuroscience

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