Abstract
A 42-year-old female with body weight loss, finger tremors and ocular discomfort was diagnosed with Graves' disease complicated with ophthalmopathy. Thiamazole therapy rapidly improved her hyperthyroidism. However, she was admitted to our hospital because her eye symptoms acutely deteriorated over a period of two weeks. She had ocular immotility, exposure keratitis, conjunctival edema, severe proptosis and visual impairment with a high titer of serum thyroid-stimulating antibody (TSAb). Methylprednisolone pulse therapy at a dose of 500 mg/day improved her eye symptoms. Although the mechanism of the progression of Graves' ophthalmopathy has not yet been elucidated, special attention should be paid to the occurrence of ophthalmopathy even after the initiation of thiamazole therapy.
| Original language | English |
|---|---|
| Pages (from-to) | 2317-2320 |
| Number of pages | 4 |
| Journal | Internal Medicine |
| Volume | 52 |
| Issue number | 20 |
| DOIs | |
| Publication status | Published - Oct 15 2013 |
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Keywords
- Graves' disease and thiamazole
- Graves' ophthalmopathy
ASJC Scopus subject areas
- Internal Medicine
Cite this
Rapid progression of Graves' ophthalmopathy despite the administration of thiamazole. / Katsuyama, Takayuki; Takeda, Masaya; Otsuka, Fumio; Toma, Kishio; Inagaki, Kenichi; Sada, Kenei; Mimura, Yukari; Ogura, Toshio; Makino, Hirofumi.
In: Internal Medicine, Vol. 52, No. 20, 15.10.2013, p. 2317-2320.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Rapid progression of Graves' ophthalmopathy despite the administration of thiamazole
AU - Katsuyama, Takayuki
AU - Takeda, Masaya
AU - Otsuka, Fumio
AU - Toma, Kishio
AU - Inagaki, Kenichi
AU - Sada, Kenei
AU - Mimura, Yukari
AU - Ogura, Toshio
AU - Makino, Hirofumi
PY - 2013/10/15
Y1 - 2013/10/15
N2 - A 42-year-old female with body weight loss, finger tremors and ocular discomfort was diagnosed with Graves' disease complicated with ophthalmopathy. Thiamazole therapy rapidly improved her hyperthyroidism. However, she was admitted to our hospital because her eye symptoms acutely deteriorated over a period of two weeks. She had ocular immotility, exposure keratitis, conjunctival edema, severe proptosis and visual impairment with a high titer of serum thyroid-stimulating antibody (TSAb). Methylprednisolone pulse therapy at a dose of 500 mg/day improved her eye symptoms. Although the mechanism of the progression of Graves' ophthalmopathy has not yet been elucidated, special attention should be paid to the occurrence of ophthalmopathy even after the initiation of thiamazole therapy.
AB - A 42-year-old female with body weight loss, finger tremors and ocular discomfort was diagnosed with Graves' disease complicated with ophthalmopathy. Thiamazole therapy rapidly improved her hyperthyroidism. However, she was admitted to our hospital because her eye symptoms acutely deteriorated over a period of two weeks. She had ocular immotility, exposure keratitis, conjunctival edema, severe proptosis and visual impairment with a high titer of serum thyroid-stimulating antibody (TSAb). Methylprednisolone pulse therapy at a dose of 500 mg/day improved her eye symptoms. Although the mechanism of the progression of Graves' ophthalmopathy has not yet been elucidated, special attention should be paid to the occurrence of ophthalmopathy even after the initiation of thiamazole therapy.
KW - Graves' disease and thiamazole
KW - Graves' ophthalmopathy
UR - http://www.scopus.com/inward/record.url?scp=84885674611&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84885674611&partnerID=8YFLogxK
U2 - 10.2169/internalmedicine.52.9009
DO - 10.2169/internalmedicine.52.9009
M3 - Article
C2 - 24126392
AN - SCOPUS:84885674611
VL - 52
SP - 2317
EP - 2320
JO - Internal Medicine
JF - Internal Medicine
SN - 0918-2918
IS - 20
ER -