Rapid progression of Graves' ophthalmopathy despite the administration of thiamazole

Takayuki Katsuyama; Masaya Takeda; Fumio Otsuka; Kishio Toma; Kenichi Inagaki; Ken Ei Sada; Yukari Mimura; Toshio Ogura; Hirofumi Makino

doi:10.2169/internalmedicine.52.9009

Rapid progression of Graves' ophthalmopathy despite the administration of thiamazole

Takayuki Katsuyama, Masaya Takeda, Fumio Otsuka, Kishio Toma, Kenichi Inagaki, Ken Ei Sada, Yukari Mimura, Toshio Ogura, Hirofumi Makino

Research output: Contribution to journal › Article › peer-review

Abstract

A 42-year-old female with body weight loss, finger tremors and ocular discomfort was diagnosed with Graves' disease complicated with ophthalmopathy. Thiamazole therapy rapidly improved her hyperthyroidism. However, she was admitted to our hospital because her eye symptoms acutely deteriorated over a period of two weeks. She had ocular immotility, exposure keratitis, conjunctival edema, severe proptosis and visual impairment with a high titer of serum thyroid-stimulating antibody (TSAb). Methylprednisolone pulse therapy at a dose of 500 mg/day improved her eye symptoms. Although the mechanism of the progression of Graves' ophthalmopathy has not yet been elucidated, special attention should be paid to the occurrence of ophthalmopathy even after the initiation of thiamazole therapy.

Original language	English
Pages (from-to)	2317-2320
Number of pages	4
Journal	Internal Medicine
Volume	52
Issue number	20
DOIs	https://doi.org/10.2169/internalmedicine.52.9009
Publication status	Published - Oct 15 2013

Keywords

Graves' disease and thiamazole
Graves' ophthalmopathy

ASJC Scopus subject areas

Internal Medicine

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10.2169/internalmedicine.52.9009

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title = "Rapid progression of Graves' ophthalmopathy despite the administration of thiamazole",

abstract = "A 42-year-old female with body weight loss, finger tremors and ocular discomfort was diagnosed with Graves' disease complicated with ophthalmopathy. Thiamazole therapy rapidly improved her hyperthyroidism. However, she was admitted to our hospital because her eye symptoms acutely deteriorated over a period of two weeks. She had ocular immotility, exposure keratitis, conjunctival edema, severe proptosis and visual impairment with a high titer of serum thyroid-stimulating antibody (TSAb). Methylprednisolone pulse therapy at a dose of 500 mg/day improved her eye symptoms. Although the mechanism of the progression of Graves' ophthalmopathy has not yet been elucidated, special attention should be paid to the occurrence of ophthalmopathy even after the initiation of thiamazole therapy.",

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author = "Takayuki Katsuyama and Masaya Takeda and Fumio Otsuka and Kishio Toma and Kenichi Inagaki and Sada, {Ken Ei} and Yukari Mimura and Toshio Ogura and Hirofumi Makino",

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AU - Katsuyama, Takayuki

AU - Takeda, Masaya

AU - Otsuka, Fumio

AU - Toma, Kishio

AU - Inagaki, Kenichi

AU - Sada, Ken Ei

AU - Mimura, Yukari

AU - Ogura, Toshio

AU - Makino, Hirofumi

PY - 2013/10/15

Y1 - 2013/10/15

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