Rapid access to indole-fused bicyclo[2.2.2]octanones by merging the umpolung strategy and molecular iodine as a green catalyst

Takumi Abe, Seiya Hirao

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

One-pot synthesis of indole-fused bicyclo[2.2.2]octanones from DiMeOIN and 2-cyclohexen-1-one is accomplished under an iodine catalyst. The simple and metal-free conditions provide a practical tool to construct Csp3-rich complex moleculesviacoupling cyclization.

Original languageEnglish
Pages (from-to)4193-4197
Number of pages5
JournalOrganic and Biomolecular Chemistry
Volume18
Issue number22
DOIs
Publication statusPublished - Jun 14 2020
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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