Rapid access to indole-fused bicyclo[2.2.2]octanones by merging the umpolung strategy and molecular iodine as a green catalyst

Takumi Abe; Seiya Hirao

doi:10.1039/d0ob01038c

Rapid access to indole-fused bicyclo[2.2.2]octanones by merging the umpolung strategy and molecular iodine as a green catalyst

Takumi Abe, Seiya Hirao

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

One-pot synthesis of indole-fused bicyclo[2.2.2]octanones from DiMeOIN and 2-cyclohexen-1-one is accomplished under an iodine catalyst. The simple and metal-free conditions provide a practical tool to construct Csp³-rich complex moleculesviacoupling cyclization.

Original language	English
Pages (from-to)	4193-4197
Number of pages	5
Journal	Organic and Biomolecular Chemistry
Volume	18
Issue number	22
DOIs	https://doi.org/10.1039/d0ob01038c
Publication status	Published - Jun 14 2020
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1039/d0ob01038c

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abstract = "One-pot synthesis of indole-fused bicyclo[2.2.2]octanones from DiMeOIN and 2-cyclohexen-1-one is accomplished under an iodine catalyst. The simple and metal-free conditions provide a practical tool to construct Csp3-rich complex moleculesviacoupling cyclization.",

author = "Takumi Abe and Seiya Hirao",

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AU - Hirao, Seiya

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Y1 - 2020/6/14

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AB - One-pot synthesis of indole-fused bicyclo[2.2.2]octanones from DiMeOIN and 2-cyclohexen-1-one is accomplished under an iodine catalyst. The simple and metal-free conditions provide a practical tool to construct Csp3-rich complex moleculesviacoupling cyclization.

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Rapid access to indole-fused bicyclo[2.2.2]octanones by merging the umpolung strategy and molecular iodine as a green catalyst

Abstract

ASJC Scopus subject areas

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