RANTES -28G delays and DC-SIGN -139C enhances AIDS progression in HIV type 1-infected Japanese hemophiliacs

Yusuke Koizumi, Seiji Kageyama, Yoshihide Fujiyama, Michiko Miyashita, Raphael Lwembe, Keiki Ogino, Tatsuo Shioda, Hiroshi Ichimura

Research output: Contribution to journalArticle

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Abstract

The relationships between host immune factors and HIV-1 disease progression are still in dispute. Unlike CCR5Δ32, which has been found to delay disease progression of HIV-1, there still remain several factors whose effect on the clinical course is unconfirmed. To clarify the relationships, we selected seven single-nucleotide polymorphisms (SNPs) out of the previously reported factors, namely, RANTES promoter -28G/-403A, RANTES In1.1C, SDF-1 3′ A, IL-4 promoter -589T, and DC-SIGN promoter -139C/-336C, and examined these in Japanese HIV-1-infected hemophiliacs (n = 102). The genotypes were examined by the direct sequencing method, and the distributions of genotype and allelic frequencies were compared between two groups, slow progressors (n = 54) who did not develop AIDS more than 10 years after intravenous infection and others (progressors) (n = 48). The allelic frequency of RANTES -28G was significantly higher in slow progressors (0.185) than in the progressor group (0.074) [p = 0.023, OR = 0.35,95% CI (0.142, 0.880)]. DC-SIGN promoter -139C appeared in progressors with significantly higher allelic frequency (0.333) than slow progressors [0.204, p = 0.040, OR = 1.95, 95% CI (1.039, 3.677)]. With RANTES -403A, RANTES In1.1C, SDF-1 3′ A, IL-4 -589T, and DC-SIGN -336C, no significant difference was observed in allelic frequencies between the two groups. These results suggest that RANTES -28G was associated with delayed AIDS progression, while DC-SIGN -139C was associated with accelerated AIDS progression in HIV-1-infected Japanese hemophiliacs.

Original languageEnglish
Pages (from-to)713-719
Number of pages7
JournalAIDS Research and Human Retroviruses
Volume23
Issue number5
DOIs
Publication statusPublished - May 2007
Externally publishedYes

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Chemokine CCL5
HIV-1
Acquired Immunodeficiency Syndrome
Interleukin-4
Disease Progression
Genotype
Dissent and Disputes
Immunologic Factors
Single Nucleotide Polymorphism
DC-specific ICAM-3 grabbing nonintegrin
Infection

ASJC Scopus subject areas

  • Immunology
  • Virology

Cite this

Koizumi, Y., Kageyama, S., Fujiyama, Y., Miyashita, M., Lwembe, R., Ogino, K., ... Ichimura, H. (2007). RANTES -28G delays and DC-SIGN -139C enhances AIDS progression in HIV type 1-infected Japanese hemophiliacs. AIDS Research and Human Retroviruses, 23(5), 713-719. https://doi.org/10.1089/aid.2006.0225

RANTES -28G delays and DC-SIGN -139C enhances AIDS progression in HIV type 1-infected Japanese hemophiliacs. / Koizumi, Yusuke; Kageyama, Seiji; Fujiyama, Yoshihide; Miyashita, Michiko; Lwembe, Raphael; Ogino, Keiki; Shioda, Tatsuo; Ichimura, Hiroshi.

In: AIDS Research and Human Retroviruses, Vol. 23, No. 5, 05.2007, p. 713-719.

Research output: Contribution to journalArticle

Koizumi, Y, Kageyama, S, Fujiyama, Y, Miyashita, M, Lwembe, R, Ogino, K, Shioda, T & Ichimura, H 2007, 'RANTES -28G delays and DC-SIGN -139C enhances AIDS progression in HIV type 1-infected Japanese hemophiliacs', AIDS Research and Human Retroviruses, vol. 23, no. 5, pp. 713-719. https://doi.org/10.1089/aid.2006.0225
Koizumi, Yusuke ; Kageyama, Seiji ; Fujiyama, Yoshihide ; Miyashita, Michiko ; Lwembe, Raphael ; Ogino, Keiki ; Shioda, Tatsuo ; Ichimura, Hiroshi. / RANTES -28G delays and DC-SIGN -139C enhances AIDS progression in HIV type 1-infected Japanese hemophiliacs. In: AIDS Research and Human Retroviruses. 2007 ; Vol. 23, No. 5. pp. 713-719.
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