TY - JOUR
T1 - Randomized trial of cefepime monotherapy or cefepime in combination with amikacin as empirical therapy for febrile neutropenia
AU - Tamura, K.
AU - Imajo, K.
AU - Akiyama, N.
AU - Sozuki, K.
AU - Urabe, A.
AU - Ohyashiki, K.
AU - Tanimoto, M.
AU - Masaoka, T.
N1 - Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.
PY - 2004/7/15
Y1 - 2004/7/15
N2 - A multicenter open randomized trial was conducted to compare cefepime monotherapy with cefepime/amikacin combination (dual) therapy in treating febrile neutropenic patients with hematologic disorders. Among the 189 evaluable patients, 5.8% had microbiologically and 10.6% had clinically documented infections. Excellent response was seen in 32.6% and 45.7% of monotherapy and dual therapy recipients, respectively, at day 3 (P = .065). At day 3, patients with neutrophil counts of <500/μL receiving dual therapy had a better response than did those receiving monotherapy (45% vs. 27.6%; P = .024). The same was true for patients with leukemia. Adverse events were minimal, and early death was observed in 7 patients in the dual therapy group and 5 patients in the monotherapy group. Overall, cefepime monotherapy is as effective as dual therapy for the initial treatment of febrile neutropenic patients. Further study is warranted for patients with severe neutropenia and leukemia who may benefit from dual therapy.
AB - A multicenter open randomized trial was conducted to compare cefepime monotherapy with cefepime/amikacin combination (dual) therapy in treating febrile neutropenic patients with hematologic disorders. Among the 189 evaluable patients, 5.8% had microbiologically and 10.6% had clinically documented infections. Excellent response was seen in 32.6% and 45.7% of monotherapy and dual therapy recipients, respectively, at day 3 (P = .065). At day 3, patients with neutrophil counts of <500/μL receiving dual therapy had a better response than did those receiving monotherapy (45% vs. 27.6%; P = .024). The same was true for patients with leukemia. Adverse events were minimal, and early death was observed in 7 patients in the dual therapy group and 5 patients in the monotherapy group. Overall, cefepime monotherapy is as effective as dual therapy for the initial treatment of febrile neutropenic patients. Further study is warranted for patients with severe neutropenia and leukemia who may benefit from dual therapy.
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U2 - 10.1086/383046
DO - 10.1086/383046
M3 - Article
C2 - 15250016
AN - SCOPUS:3242786240
VL - 39
SP - S15-S24
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
SN - 1058-4838
IS - SUPPL. 1
ER -