Raloxifene inhibits hepatitis C virus infection and replication

Midori Takeda, Masanori Ikeda, Kyoko Mori, Masahiko Yano, Yasuo Ariumi, Hiromichi Dansako, Takaji Wakita, Nobuyuki Kato

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Postmenopausal women with chronic hepatitis C exhibited a poor response to interferon (IFN) therapy compared to premenopausal women. Osteoporosis is the typical complication that occurs in postmenopausal women. Recently, it was reported that an osteoporotic reagent, vitamin D3, exhibited anti-hepatitis C virus (HCV) activity. Therefore, we investigated whether or not another osteoporotic reagent, raloxifene, would exhibit anti-HCV activity in cell culture systems. Here, we demonstrated that raloxifene inhibited HCV RNA replication in genotype 1b and infection in genotype 2a. Raloxifene enhanced the anti-HCV activity of IFN-α. These results suggest a link between the molecular biology of osteoporosis and the HCV life cycle.

Original languageEnglish
Pages (from-to)279-283
Number of pages5
JournalFEBS Open Bio
Volume2
DOIs
Publication statusPublished - 2012

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Keywords

  • Estrogen
  • Hepatitis C virus
  • Osteoporosis
  • Raloxifene
  • Statin

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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